Wu HB, Chen T, Tian Y. Letter to the Editor: Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions. World J Gastroenterol 2026; 32(27): 119545 [DOI: 10.3748/wjg.119545]
Corresponding Author of This Article
Yi Tian, MD, Doctor, Department of Clinical Medical, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, No. 522 Xiwaita Stone Road, Tongchuan District, Dazhou 635000, Sichuan Province, China. doc.yitian@hotmail.com
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Gastroenterology & Hepatology
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letter
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Wu HB, Chen T, Tian Y. Letter to the Editor: Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions. World J Gastroenterol 2026; 32(27): 119545 [DOI: 10.3748/wjg.119545]
World J Gastroenterol. Jul 21, 2026; 32(27): 119545 Published online Jul 21, 2026. doi: 10.3748/wjg.119545
Letter to the Editor: Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions
Hai-Bo Wu, Ting Chen, Yi Tian
Hai-Bo Wu, Yi Tian, Department of Clinical Medical, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou 635000, Sichuan Province, China
Ting Chen, Department of Clinical Medical, Sichuan University West China Hospital Yingshan Hospital & Yingshan People’s Hospital, Nanchong 637000, Sichuan Province, China
Co-first authors: Hai-Bo Wu and Ting Chen.
Author contributions: Wu HB and Chen T contributed equally to this manuscript and are co-first authors. Wu HB contributed to writing - original draft; Chen T contributed to formal analysis; Tian Y contributed to conceptualization.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Yi Tian, MD, Doctor, Department of Clinical Medical, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, No. 522 Xiwaita Stone Road, Tongchuan District, Dazhou 635000, Sichuan Province, China. doc.yitian@hotmail.com
Received: January 30, 2026 Revised: February 13, 2026 Accepted: March 10, 2026 Published online: July 21, 2026 Processing time: 158 Days and 21.6 Hours
Abstract
The study by Wang et al, published in the recent issue of the World Journal of Gastroenterology, which on the age-related gut microbiome profile and reversal of microbial imbalance using trimetazidine therapy. This study provided compelling evidence that the gut microbiota undergoes significant age-dependent changes, particularly an enrichment of fatty acid oxidation-related microbes in older populations. The authors successfully demonstrated that trimetazidine restored the gut microbial balance and reduced senescence markers in ageing rats, indicating that it exerts potential anti-ageing effects by modulating the microbiota and metabolism. We commend the innovative multi-cohort design of the study, in which human cross-sectional data were integrated with longitudinal rat models to enhance our understanding of microbial dynamics across the organism lifespan. However, we also acknowledge limitations of the study, including the need to further explore causal mechanisms, the lack of metabolomic data, and potential geographical bias from sample collection. Future multicentre studies are warranted to validate and expand the clinical applicability of the findings regarding the gut microbiota-fatty acid oxidation axis in ageing.
Core Tip: In this letter, we discuss a study by Wang et al on the age-related gut microbiome profile and reversal of microbial imbalance using trimetazidine therapy. This study provided compelling evidence that the gut microbiota undergoes significant age-dependent changes, particularly an enrichment of fatty acid oxidation-related microbes in older populations. The authors successfully demonstrated that trimetazidine restored the gut microbial balance and reduced senescence markers in ageing rats, indicating that it exerts potential anti-ageing effects by modulating the microbiota and metabolism.
