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World J Gastroenterol. May 7, 2026; 32(17): 117558
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117558
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117558
Improved prognostic stratification of the revised ninth edition American Joint Committee on Cancer staging system for colorectal cancer
Zhi-Gang Sun, Shao-Xuan Chen, Jian-Zheng Jie, Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Wen-Xiao Wu, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100029, China
Ya-Jun Zhang, Department of Anesthesiology, China-Japan Friendship Hospital, Beijing 100029, China
Co-first authors: Zhi-Gang Sun and Wen-Xiao Wu.
Co-corresponding authors: Ya-Jun Zhang and Jian-Zheng Jie.
Author contributions: Sun ZG, Wu WX, Zhang YJ, Jie JZ designed the research; Jie JZ, Chen SX assisted in data collection; Wu WX performed literature search, manuscript preparation and statistical analysis; Sun ZG carried out manuscript editing and manuscript review; all authors have read and approved the final manuscript.
Supported by the National Key Research and Development Program of China, No. 2024YFE0198300; and National High Level Hospital Clinical Research Funding, No. 2023-NHLHCRF-BQ-32 and No. 2023-NHLHCRF-YYPPLC-ZR-13.
Institutional review board statement: This study was reviewed and approved by the China-Japan Friendship Hospital Review Board, No. 2024-KY-0147.
Informed consent statement: The requirement to obtain informed consent was waived.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Corresponding author: Jian-Zheng Jie, MD, Chief Physician, Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. jianzhengjie@sohu.com
Received: December 12, 2025
Revised: January 12, 2026
Accepted: February 11, 2026
Published online: May 7, 2026
Processing time: 132 Days and 19.5 Hours
Revised: January 12, 2026
Accepted: February 11, 2026
Published online: May 7, 2026
Processing time: 132 Days and 19.5 Hours
Core Tip
Core Tip: This validation study of 2413 stage I-III colon and rectal cancer patients demonstrates that the proposed 9th edition American Joint Committee on Cancer staging system shows clearer hierarchical separation in overall and disease-free survival, offering better prognostic discrimination compared to the 8th edition.