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World J Gastroenterol. May 7, 2026; 32(17): 117544
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117544
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117544
Helicobacter pylori eradication and the prevention of peptic ulcer bleeding and cardiovascular disease progression in chronic aspirin users
Atteyat A Semeya, Department of Hepatology, Gastroenterology and Infectious Diseases, Benha Teaching Hospital, Benha 13511, Egypt
Wael Ahmed Makled, Department of Cardiology, Benha Teaching Hospital, Benha 13511, Egypt
Mohamed A Elnagdy, Department of Gastroenterology and Infectious Disease, National Liver Institute, Shebin El-Kom 32515, Menoufia, Egypt
Rasha Elgamal, Department of Clinical Pathology, Faculty of Medicine, Suez University, Suez 43511, Suez, Egypt
Amira A A Othman, Department of Internal Medicine, Suez University, Suez 43511, Suez, Egypt
Author contributions: Semeya AA contributed to data acquisition, statistical analysis, interpreted the results, analyzed the data, and agreed to be accountable for all aspects of the work; Makled WA, Elnagdy MA and Elgamal R contributed to data acquisition, analyzed the data; Othman AAA contributed to interpreted the results, analyzed the data; and all authors contributed to concept and design of the study, drafted the manuscript, critically revised the manuscript, and approved the final version to be published.
Institutional review board statement: The study was conducted after obtaining approval from the Ethics Committee of Benha Teaching Hospitals, Egypt, Approval No. HB-000131.
Informed consent statement: All subjects were informed and gave their voluntary, written informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All relevant data are included in this published article.
Corresponding author: Amira A A Othman, MD, PhD, Lecturer, Principal Investigator, Depar
Received: December 10, 2025
Revised: January 1, 2026
Accepted: February 12, 2026
Published online: May 7, 2026
Processing time: 135 Days and 19 Hours
Revised: January 1, 2026
Accepted: February 12, 2026
Published online: May 7, 2026
Processing time: 135 Days and 19 Hours
Core Tip
Core Tip: This prospective observational study shows that persistent Helicobacter pylori infection markedly increases the risk of peptic ulcer bleeding and cardiovascular (CV) disease progression in long-term low-dose aspirin users. Successful eradication lowered ulcer bleeding rates from 11.9% to 3.7% - an approximately 69% relative risk reduction and was associated with significantly fewer CV events. These findings support routine Helicobacter pylori screening and eradication as a practical strategy to improve both gastrointestinal safety and CV outcomes in high-risk aspirin users.