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World J Gastroenterol. May 7, 2026; 32(17): 117479
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117479
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117479
Proposal of a new classification scheme for complete portal vein thrombosis and its clinical significance: A retrospective study
Yi-Fan Lv, Bo-Wen Liu, Dong-Ze Li, Hua Tian, Fu-Chuan Wang, Jing-Hui Dong, Fu-Quan Liu, Liver Vascular Disease Diagnosis and Treatment Center, The Fifth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100039, China
Yi-Fan Lv, Ming-Ming Meng, Fu-Quan Liu, Liver Disease Minimally Invasive Diagnosis and Treatment Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Ying Han, Hui-Guo Ding, Yue-Ning Zhang, Department of Gastroenterology and Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing 100069, China
Yong-Ping Yang, Bing Zhu, Department of Liver Diseases, The Fifth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100039, China
Guang-De Zhou, Department of Pathology, Beijing You’an Hospital, Capital Medical Uni
Co-corresponding authors: Fu-Quan Liu and Bing Zhu.
Author contributions: Ding HG, Zhang YN, Yang YP, Zhu B and Liu FQ designed the research; Lv YF, Liu BW, Han Y, Meng MM, Li DZ, Tian H, Wang FC and Dong JH performed the research; Zhou GD provided pathological information; Lv YF analyzed the data and wrote the paper; Zhu B and Liu FQ reviewed and edited the manuscript; all the authors read and approved the manuscript.
Supported by the Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project, No. 2025ZD01906302; and the Talent Training Plan During the “14th Five-Year Plan” of Beijing Shijitan Hospital Affiliated with Capital Medical University, No. 2023 LJRCLFQ.
Institutional review board statement: The study was approved by the Ethics Committee and Institutional Review Board of Beijing Shijitan Hospital (No. 2018-1-2081), Beijing You’an Hospital (No. 2023-083) and the Fifth Medical Center of Chinese PLA General Hospital (No. KY-2023-12-83-1).
Informed consent statement: All patients provided written informed consent to participate in this study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Bing Zhu, MD, Doctor, Department of Liver Diseases, The Fifth Medical Center of Chinese People’s Liberation Army General Hospital, No. 100 West Fourth Ring Middle Road, Fengtai District, Beijing 100039, China. zhubing302@163.com
Received: December 9, 2025
Revised: January 7, 2026
Accepted: February 6, 2026
Published online: May 7, 2026
Processing time: 137 Days and 2.1 Hours
Revised: January 7, 2026
Accepted: February 6, 2026
Published online: May 7, 2026
Processing time: 137 Days and 2.1 Hours
Core Tip
Core Tip: This study aimed to analyze contrast-enhanced computed tomography imaging features of complete portal vein thrombosis and establish a novel imaging-based classification system with clinical relevance. In a retrospective multicenter analysis of 171 patients, thrombus samples from 102 cases were examined pathologically. Four distinct thrombus types were identified: Acute (26.9%), chronic (34.5%), cavernous transformation (12.9%), and mixed (25.7%), each characterized by specific radiological and pathological profiles. Treatment resulted in a significant reduction in portal pressure gradient across all groups (P < 0.001), supporting the clinical utility of the proposed classification in guiding therapeutic strategy.