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World J Gastroenterol. May 7, 2026; 32(17): 116590
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.116590
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.116590
Niu Huang mitigates dextran sulfate sodium-induced colitis by modulating farnesoid X receptor activation and the complement 3/NLRP3 signaling pathway
Juan Shi, Tian Xu, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Juan Shi, Chong-Yang Ma, Xiao-Hui Zhang, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
Kun-Jing Liu, Qing-Guo Wang, Xue-Qian Wang, Fa-Feng Cheng, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Jin-Ying Liu, College of Traditional Chinese Medicine, Chengde Medical University, Chengde, Chengde 067000, Hebei Province, China
Co-first authors: Juan Shi and Chong-Yang Ma.
Co-corresponding authors: Fa-Feng Cheng and Tian Xu.
Author contributions: Shi J and Ma CY performed the research and wrote the original draft, they contributed equally to this article, they are the co-first authors of this manuscript; Zhang XH, Liu KJ, and Liu JY acquired and analyzed the data; Wang QG and Wang XQ developed methodology; Ma CY, Liu JY, and Xu T acquired funding; Cheng FF and Xu T designed the research study, participated in review and editing, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82374165, No. 82405050, and No. 82004327; Fundamental Research Funds for the Central Universities, China, No. 3332024017; and Research Project of Hebei Provincial Administration of Traditional Chinese Medicine, No. 2025086.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Capital Medical University, approval No. AEEI-2024-007.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data in the research will be made available on request.
Corresponding author: Tian Xu, Postdoc, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wang
Received: November 18, 2025
Revised: January 7, 2026
Accepted: February 12, 2026
Published online: May 7, 2026
Processing time: 160 Days and 17.4 Hours
Revised: January 7, 2026
Accepted: February 12, 2026
Published online: May 7, 2026
Processing time: 160 Days and 17.4 Hours
Core Tip
Core Tip: This study demonstrates that Niu Huang effectively alleviates ulcerative colitis. By identifying its active com