Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Apr 28, 2026; 32(16): 117443
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.117443
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.117443
Research progress in the treatment of ulcerative colitis with natural products
Xiao Yu, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
Xiao Yu, Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China
Chuan-Xi Zhao, Chao Wang, Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
Chao Wang, Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China
Co-first authors: Xiao Yu and Chuan-Xi Zhao.
Author contributions: Yu X and Zhao CX contributed equally to this article; Yu X reviewed the literature and wrote the first draft of the paper; Zhao CX and Wang C contributed to searching the literature and edited it extensively; Wang C conceived the idea and edited it.
Supported by the Natural Science Foundation of Jilin Province, No. YDZJ202401182ZYTS.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Chao Wang, MD, Doctor, Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, No. 440 Jiyan Highway, Jinan 250117, Shandong Province, China.
Received: December 8, 2025
Revised: January 16, 2026
Accepted: February 13, 2026
Published online: April 28, 2026
Processing time: 131 Days and 2.8 Hours
Revised: January 16, 2026
Accepted: February 13, 2026
Published online: April 28, 2026
Processing time: 131 Days and 2.8 Hours
Core Tip
Core Tip: This review summarizes recent research advances in natural products for ulcerative colitis, systematically analyzes their core bioactive components and potential mechanisms of action, and further identifies the challenges in clinical translation. In the future, it is imperative to clarify their therapeutic targets and conduct standardized clinical studies to facilitate the development of natural products as novel therapeutic agents or adjuvants for ulcerative colitis treatment.