Liu M, Guo C, Zhang P, Liu SM. Letter to the Editor: Unveiling a novel vitamin D receptor signaling pathway for allyl isothiocyanate against metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(16): 116951 [DOI: 10.3748/wjg.v32.i16.116951]
Corresponding Author of This Article
Peng Zhang, PhD, Medical Basic Experiment Teaching Center, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Lixia District, Jinan 250012, Shandong Province, China. zhangpeng1990@sdu.edu.cn
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Gastroenterology & Hepatology
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Apr 28, 2026 (publication date) through Apr 17, 2026
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World Journal of Gastroenterology
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1007-9327
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Liu M, Guo C, Zhang P, Liu SM. Letter to the Editor: Unveiling a novel vitamin D receptor signaling pathway for allyl isothiocyanate against metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(16): 116951 [DOI: 10.3748/wjg.v32.i16.116951]
World J Gastroenterol. Apr 28, 2026; 32(16): 116951 Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.116951
Letter to the Editor: Unveiling a novel vitamin D receptor signaling pathway for allyl isothiocyanate against metabolic dysfunction-associated steatotic liver disease
Ming Liu, Chun Guo, Peng Zhang, Shang-Ming Liu
Ming Liu, Key Laboratory of Selection and Functional Assessment of Athletes, General Administration of Sport (Hubei Institute of Sports Science), Wuhan 430205, Hubei Province, China
Chun Guo, Peng Zhang, Shang-Ming Liu, Medical Basic Experiment Teaching Center, School of Basic Medical Sciences, Shandong University, Jinan 250012, Shandong Province, China
Co-first authors: Ming Liu and Chun Guo.
Co-corresponding authors: Peng Zhang and Shang-Ming Liu.
Author contributions: Liu M and Guo C were primarily responsible for drafting this letter; Liu M and Guo C made equal contributions as co-first authors; Liu SM provided valuable suggestions; Zhang P meticulously revised the letter; Zhang P and Liu SM made equal contributions as co-corresponding authors; all authors approved the final version to publish.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Peng Zhang, PhD, Medical Basic Experiment Teaching Center, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Lixia District, Jinan 250012, Shandong Province, China. zhangpeng1990@sdu.edu.cn
Received: November 28, 2025 Revised: December 15, 2025 Accepted: February 3, 2026 Published online: April 28, 2026 Processing time: 141 Days and 9.3 Hours
Core Tip
Core Tip: Gao et al identify a novel pathway for allyl isothiocyanate-mediated improvement of metabolic dysfunction-associated steatotic liver disease, involving the activation of the vitamin D receptor (VDR) signaling pathway in hepatocytes. We further propose that transient receptor potential ankyrin 1-mediated calcium signaling may act upstream of VDR activation, offering an alternative mechanistic insight. Future work needs to give priority to validating causality, particularly through VDR-knockout models and well-characterized in vivo models, such as high-fat diet or genetic metabolic dysfunction-associated steatotic liver disease models. This would allow researchers to evaluate the impact of allyl isothiocyanate, which is crucial for therapeutic translation.
