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World J Gastroenterol. Apr 14, 2026; 32(14): 114331
Published online Apr 14, 2026. doi: 10.3748/wjg.v32.i14.114331
Published online Apr 14, 2026. doi: 10.3748/wjg.v32.i14.114331
MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer
Hong Gao, Dong-Feng Yin, Xiang-Rong Xing, Li-Jiang Zhou, Department of Oncology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Rui Yu, Department of Technology, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Author contributions: Gao H contributed to study design, data analysis, drafting the manuscript and revision of the manuscript; Yin DF, Xing XR, Zhou LJ contributed to data collection and analysis, drafting the manuscript, investigation; Yu R contributed to study design, methodology, review and editing the manuscript; and all authors read and approved the final version of the manuscript.
Supported by the Liaoning University of Traditional Chinese Medicine, No. YXIL-2024-1700-0524.
Institutional animal care and use committee statement: The procedures for care and use of animals were approved by the Ethics Committee of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and all applicable institutional and governmental regulations concerning the ethical use of animals were followed.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Corresponding author: Rui Yu, Department of Technology, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Huanggu District, Shenyang 110032, Liaoning Province, China. ruiyu690923@163.com
Received: September 28, 2025
Revised: November 14, 2025
Accepted: January 29, 2026
Published online: April 14, 2026
Processing time: 186 Days and 20.3 Hours
Revised: November 14, 2025
Accepted: January 29, 2026
Published online: April 14, 2026
Processing time: 186 Days and 20.3 Hours
Core Tip
Core Tip: Xiangshaliujunzi decoction (XSLJZD) overcomes 5-fluorouracil (5-FU) resistance in gastric cancer by inducing PANoptosis via the miR-200a-3p/ZEB1/IRF1 pathway. In vitro, XSLJZD inhibits viability and promotes cell death. In vivo, combination with 5-FU enhances this effect. This provides a novel traditional Chinese medicine strategy for chemoresistance, though limitations include lack of standalone controls and generalizability validation.