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World J Gastroenterol. Apr 7, 2026; 32(13): 115758
Published online Apr 7, 2026. doi: 10.3748/wjg.v32.i13.115758
Published online Apr 7, 2026. doi: 10.3748/wjg.v32.i13.115758
Biological welding: A rapid and bloodless approach to hemorrhoidectomy
Yuan Chen, Qian-Rui Zhang, Ming-Gan Guo, Fan-Chun Zeng, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Yuan Chen, Zhong-Yi Sun, Fan-Chun Zeng, Urology and Reproduction Medicine Center, Renji Hospital, School of Medicine, Chongqing University, Chongqing 400044, China
Qian-Rui Zhang, Henan University Medical School, Henan University, Kaifeng 475001, Henan Province, China
Co-first authors: Yuan Chen and Qian-Rui Zhang.
Co-corresponding authors: Zhong-Yi Sun and Fan-Chun Zeng.
Author contributions: Chen Y, Zhang QR, Guo MG, and Zeng FC were responsible for collection and assembly of data; Sun ZY conducted the data analysis and interpretation; Zeng FC, Chen Y, and Zhang QR primarily drafted the manuscript; Sun ZY performed critical revision of the manuscript for important intellectual content; all authors reviewed the final manuscript and approved the version to be published.
Supported by the Shenzhen Science and Technology Program, No. JCYJ20220531103004008; the Talent Introduction Program of Renji Hospital Affiliated to Chongqing University, No. 20251028-06; and Medicine-Engineering Interdisciplinary Research Foundation of Shenzhen University, No. 2023YG018.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: All experiments involving animals have been reviewed and approved by the Institutional Animal Care and Use Committee of Shenzhen University Medical School (No. IACUC-202400075).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Fan-Chun Zeng, MD, Doctor, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, No. 3688 Nanhai Avenue, Nanshan District, Shenzhen 518060, Guangdong Province, China. zengisle@szu.edu.cn
Received: October 31, 2025
Revised: November 19, 2025
Accepted: January 21, 2026
Published online: April 7, 2026
Processing time: 154 Days and 3.4 Hours
Revised: November 19, 2025
Accepted: January 21, 2026
Published online: April 7, 2026
Processing time: 154 Days and 3.4 Hours
Core Tip
Core Tip: This study demonstrates that biological welding technology, which integrates tissue fusion, cutting, and hemostasis into a single procedure, offers a rapid and bloodless approach to hemorrhoidectomy. In a rabbit model, it significantly reduced operative time by approximately 80%, achieved zero intraoperative blood loss, and accelerated postoperative recovery compared to traditional excision and suturing. Mechanistically, it promotes organized tissue repair by remodeling collagen fibers and reducing inflammation. These findings highlight its potential as a safe, efficient, and innovative surgical technique for clinical application in the treatment of hemorrhoids.