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World J Gastroenterol. Mar 28, 2026; 32(12): 115853
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.115853
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.115853
Microbiome-immune interactions in autoimmune liver diseases
Yana Kiseleva, Roman Maslennikov, Elena Poluektova, Oksana Zolnikova, Elena Shirokova, Vladimir Ivashkin, Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow 119435, Russia
Elena Poluektova, Scientific Community for Human Microbiome Research, Moscow 119435, Russia
Alexey Sigidaev, Department of Clinical Disciplines, Tyumen State Medical University, Tyumen 625023, Russia
Alexey Sigidaev, Coordination and Analytical Center for Chemical and Biological Safety, Sechenov University, Moscow 119435, Russia
Yury Zharikov, Department of Human Anatomy and Histology, Sechenov University, Moscow 125009, Russia
Author contributions: Ivashkin V, Poluektova E, and Maslennikov R conceived the idea for this review; Kiseleva Y written the main text; Maslennikov R, Ivashkin V, Poluektova E, Zolnikova O, Sigidaev A, Zarikov Y, and Shirokova E edited the sections on autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Roman Maslennikov, MD, Associate Professor, Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya str., 1, bld. 1, Moscow 119435, Russia. mmmm00@yandex.ru
Received: October 28, 2025
Revised: December 29, 2025
Accepted: January 20, 2026
Published online: March 28, 2026
Processing time: 143 Days and 5.9 Hours
Revised: December 29, 2025
Accepted: January 20, 2026
Published online: March 28, 2026
Processing time: 143 Days and 5.9 Hours
Core Tip
Core Tip: The impact of gut microbiota on immune regulation has received increasing attention in recent years, particularly its role in the onset and progression of immune-mediated liver disorders. Disturbances in the microbial balance compromise the intestinal barrier and trigger abnormal immune activity, which foster persistent inflammation, autoimmunity and subsequent liver damage. A deeper understanding of the gut-liver axis is expected to support the creation of more effective approaches aimed at improving prognosis and enhancing patients’ quality of life.