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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2026; 32(1): 113232
Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.113232
Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.113232
Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials
Fu Tian, Zhi-Cheng Huang, Kai Qiu, Department of Intensive Care Unit, Hangzhou Geriatric Hospital, Hangzhou 310022, Zhejiang Province, China
Hayat Khizar, Department of Surgery, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 320000, Zhejiang Province, China
Author contributions: Tian F and Huang ZC contributed to writing the original paper, retrieved the articles, and did data extraction and data analysis; Khizar H was responsible for image editing, correction, and data analysis; Qiu K was responsible for provided article ideas and article review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai Qiu, MD, Department of Intensive Care Unit, Hangzhou Geriatric Hospital, No. 50 Jingshen Road, Hangzhou 310022, Zhejiang Province, China.
Received: August 19, 2025
Revised: September 3, 2025
Accepted: September 30, 2025
Published online: January 7, 2026
Processing time: 139 Days and 0.7 Hours
Revised: September 3, 2025
Accepted: September 30, 2025
Published online: January 7, 2026
Processing time: 139 Days and 0.7 Hours
Core Tip
Core Tip: This meta-analysis assessed the efficacy of rectal indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis by reviewing the results of 30 randomized controlled trials. Indomethacin didn’t show a significant reduction in overall post-endoscopic retrograde cholangiopancreatography pancreatitis rates or adverse events relative to controls, however, it may be beneficial in particular high-risk patients, but with caution given to significant heterogeneity in the results.