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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2025; 31(45): 113332
Published online Dec 7, 2025. doi: 10.3748/wjg.v31.i45.113332
Published online Dec 7, 2025. doi: 10.3748/wjg.v31.i45.113332
Herbal formulas and gastrointestinal motility: Bridging traditional medicine and mechanistic insights
Michal Zalzman, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
Michal Zalzman, Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States
Aditi Banerjee, Department of Pediatrics, University of Maryland School of Medicine, Bal
Author contributions: Zalzman M reviewed and edited the manuscript; Banerjee A conceptualized the work, wrote the original draft, and completed the final draft before the first author read and approved the final version. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aditi Banerjee, PhD, Associate Professor, Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, United States. aditi.banerjee@som.umaryland.edu
Received: August 22, 2025
Revised: September 7, 2025
Accepted: November 4, 2025
Published online: December 7, 2025
Processing time: 103 Days and 16.8 Hours
Revised: September 7, 2025
Accepted: November 4, 2025
Published online: December 7, 2025
Processing time: 103 Days and 16.8 Hours
Core Tip
Core Tip: Functional gastrointestinal disorders such as dyspepsia encompass complex pathophysiological mechanisms for which safe and effective treatments remain limited. This research provides new evidence that traditional herbal formulas can ameliorate cold stress induced impairment of gastrointestinal motility in a mouse model, offering mechanistic insight into their therapeutic potential. Additionally, this research demonstrates that standard methods could link traditional herbal practices with modern treatments. Further translational research is needed to monitor the impact of these methods on patients suffering from functional dyspepsia.