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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2025; 31(42): 112107
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.112107
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.112107
Expanding the role of radiomics and artificial intelligence in the management of inflammatory bowel disease: Insights, opportunities, and challenges
Zhi-Gang Liu, Shan-Shan Xie, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China
Zhi-Gang Liu, Shan-Shan Xie, Zhejiang Key Laboratory of Neonatal Diseases, Hangzhou 310052, Zhejiang Province, China
Zhi-Gang Liu, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK
Shan-Shan Xie, Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China
Co-corresponding authors: Zhi-Gang Liu and Shan-Shan Xie.
Author contributions: Liu ZG and Xie SS jointly supervised the study and contributed equally as co-corresponding authors to the conception, organization, and final approval of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shan-Shan Xie, Professor, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou 310052, Zhejiang Province, China. sxie@zju.edu.cn
Received: July 17, 2025
Revised: September 2, 2025
Accepted: October 13, 2025
Published online: November 14, 2025
Processing time: 118 Days and 22.6 Hours
Revised: September 2, 2025
Accepted: October 13, 2025
Published online: November 14, 2025
Processing time: 118 Days and 22.6 Hours
Core Tip
Core Tip: Radiomics and artificial intelligence are emerging as powerful tools in the management of inflammatory bowel disease (IBD), particularly in predicting secondary loss of response to biologic therapies like infliximab. By integrating imaging data with clinical and laboratory parameters, these technologies offer a more personalized, proactive approach to disease management, enabling earlier interventions and optimizing treatment plans for Crohn’s disease and ulcerative colitis. While challenges remain in standardization and clinical adoption, the potential to transform IBD care with precision medicine is significant.