Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256 [PMID: 41257279 DOI: 10.3748/wjg.v31.i41.111256]
Corresponding Author of This Article
Xian-Bo Wang, MD, Chief Physician, Professor, Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing 100015, China. wangxb@ccmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256 [PMID: 41257279 DOI: 10.3748/wjg.v31.i41.111256]
World J Gastroenterol. Nov 7, 2025; 31(41): 111256 Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.111256
Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis
Jia-Liang Chen, Yi-Xin Hou, Yao Liu, Yu-Yong Jiang, Xian-Bo Wang
Jia-Liang Chen, Yi-Xin Hou, Yao Liu, Yu-Yong Jiang, Xian-Bo Wang, Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Author contributions: Chen JL, Hou YX, Liu Y, Jiang YY, and Wang XB contributed to material preparation, data collection, and analysis. Chen JL wrote the first draft of the manuscript; Wang XB supervised the report. All authors contributed to the study conception and design, read and approved the final manuscript.
Supported by the Capital’s Funds for Health Improvement and Research, No. CFH2024-1-2173; State Administration of Traditional Chinese Medicine High-Level Key Disciplines Construction Project, No. zyyzdxk-2023005; and the Scientific Research Fund Project of Beijing Ditan Hospital, No. DTDR202403.
Institutional review board statement: The study protocol was conducted in accordance with the Helsinki Declaration of 1975 and approved by the Ethics Committee of Beijing Ditan Hospital, Beijing, China (No. DTEC-KT2022-010-01).
Informed consent statement: As this study used anonymous and pre-existing data, the requirement for informed consent from patients was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Xian-Bo Wang, MD, Chief Physician, Professor, Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing 100015, China. wangxb@ccmu.edu.cn
Received: June 26, 2025 Revised: August 13, 2025 Accepted: September 24, 2025 Published online: November 7, 2025 Processing time: 133 Days and 15.1 Hours
Core Tip
Core Tip: This study retrospectively used vibration-controlled transient elastography (VCTE) to assess advanced fibrosis using liver stiffness measurement (LSM) in Chinese patients with histologically verified primary biliary cholangitis (PBC). To our knowledge, this study is currently the largest sample size among similar studies exploring VCTE for evaluating PBC fibrosis. Furthermore, this study provides a dual cut-off approach utilizing LSM through VCTE to categorize individuals with PBC into three categories of risk: Early-stage (LSM ≤ 10.0 kPa), advanced-stage (LSM > 14.5 kPa), and a grey area of inaccurate discrimination. This non-invasive method of individual risk stratification for PBC will aid in the selection of clinical decisions.
