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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2025; 31(41): 111174
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.111174
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.111174
Mechanisms of ferroptosis in primary hepatocellular carcinoma and progress of artificial intelligence-based predictive modeling in hepatocellular carcinoma
Jiang-Feng Han, Wen-Qiao Zang, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan Province, China
Jiang-Feng Han, Zi-Yao Jia, The First Clinical Medical College, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Xiang Fan, The Fifth Clinical Medical College of Henan University of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450099, Henan Province, China
Xue-Yan Zhao, Xiao-Ran Ji, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Li-Ye Cheng, The Third Clinical Medical College, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Yu-Xuan Xia, The Fifth Clinical Medical College, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Han JF contributed to the manuscript writing - review & editing and writing - original draft; Han JF, Jia ZY, Cheng LY, Xia YX, and Ji XR contributed to the investigation; Han JF, Jia ZY, Fan X, Zhao XY, Cheng LY, Xia YX, and Ji XR contributed to the formal analysis; Han JF and Jia ZY contributed to the image organization; Zang WQ contributed to the validation, supervision, and conceptualization.
Supported by Henan Provincial Science and Technology Research Project, No. 252102311168 and No. 242102310066; and the Medical Education Research Project in Henan Province, No. WJLX2024153.
Conflict-of-interest statement: Zang WQ reports grants from Research Funding from Science and Technology Department of Henan Province, during the conduct of the study.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Qiao Zang, Professor, College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, Zhengzhou 450000, Henan Province, China.
Received: June 26, 2025
Revised: August 3, 2025
Accepted: October 14, 2025
Published online: November 7, 2025
Processing time: 134 Days and 20.6 Hours
Revised: August 3, 2025
Accepted: October 14, 2025
Published online: November 7, 2025
Processing time: 134 Days and 20.6 Hours
Core Tip
Core Tip: The molecular mechanisms of ferroptosis have been systematically inves