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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2025; 31(39): 110751
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110751
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110751
Influence of blood transfusion on postoperative inflammation, stress markers, and prognosis in patients with gastric cancer
Yan-Qin Chen, Department of Laboratory Medicine, Yiwu Central Hospital, Yiwu 322000, Zhejiang Province, China
Jian-Hui Chen, Yi-Xin Zhang, Lei-Lei Fu, Xiao-Shuang Luo, Department of Blood Transfusion, Yiwu Central Hospital, Yiwu 322000, Zhejiang Province, China
Co-first authors: Yan-Qin Chen and Jian-Hui Chen.
Author contributions: Chen YQ and Chen JH are co-first authors and contributed equally to this work, including design of the study, acquiring and analyzing data from experiments, and writing of the manuscript; Chen YQ and Chen JH designed the experiments and conducted clinical data collection; Zhang YX, Fu LL and Luo XS performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Chen YQ and Chen JH make critical revisions to important knowledge content; all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Yiwu Central Hospital (No. K2025-IRB-042).
Informed consent statement: The Ethics Committee agreed to waive informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Hui Chen, MD, Doctor, Department of Blood Transfusion, Yiwu Central Hospital, No. 699 Jiangdong Road, No. 519 Nanmen Street, Yiwu 322000, Zhejiang Province, China. chen_jh001@126.com
Received: July 22, 2025
Revised: August 22, 2025
Accepted: September 26, 2025
Published online: October 21, 2025
Processing time: 91 Days and 1.3 Hours
Revised: August 22, 2025
Accepted: September 26, 2025
Published online: October 21, 2025
Processing time: 91 Days and 1.3 Hours
Core Tip
Core Tip: This study aimed to investigate the impact of blood transfusion on postoperative inflammation and stress markers in gastric cancer patients undergoing radical gastrectomy, and its correlation with prognosis. Perioperative blood transfusion is associated with increased postoperative inflammation, stress reactions, complication rates, and adverse prognosis in gastric cancer patients. Reducing unnecessary transfusions can improve postoperative recovery and long-term prognosis.