Chen YQ, Chen JH, Zhang YX, Fu LL, Luo XS. Influence of blood transfusion on postoperative inflammation, stress markers, and prognosis in patients with gastric cancer. World J Gastroenterol 2025; 31(39): 110751 [DOI: 10.3748/wjg.v31.i39.110751]
Corresponding Author of This Article
Jian-Hui Chen, MD, Doctor, Department of Blood Transfusion, Yiwu Central Hospital, No. 699 Jiangdong Road, No. 519 Nanmen Street, Yiwu 322000, Zhejiang Province, China. chen_jh001@126.com
Research Domain of This Article
Gastroenterology & Hepatology
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 21, 2025 (publication date) through Oct 21, 2025
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Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Chen YQ, Chen JH, Zhang YX, Fu LL, Luo XS. Influence of blood transfusion on postoperative inflammation, stress markers, and prognosis in patients with gastric cancer. World J Gastroenterol 2025; 31(39): 110751 [DOI: 10.3748/wjg.v31.i39.110751]
World J Gastroenterol. Oct 21, 2025; 31(39): 110751 Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110751
Influence of blood transfusion on postoperative inflammation, stress markers, and prognosis in patients with gastric cancer
Yan-Qin Chen, Jian-Hui Chen, Yi-Xin Zhang, Lei-Lei Fu, Xiao-Shuang Luo
Yan-Qin Chen, Department of Laboratory Medicine, Yiwu Central Hospital, Yiwu 322000, Zhejiang Province, China
Jian-Hui Chen, Yi-Xin Zhang, Lei-Lei Fu, Xiao-Shuang Luo, Department of Blood Transfusion, Yiwu Central Hospital, Yiwu 322000, Zhejiang Province, China
Co-first authors: Yan-Qin Chen and Jian-Hui Chen.
Author contributions: Chen YQ and Chen JH are co-first authors and contributed equally to this work, including design of the study, acquiring and analyzing data from experiments, and writing of the manuscript; Chen YQ and Chen JH designed the experiments and conducted clinical data collection; Zhang YX, Fu LL and Luo XS performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Chen YQ and Chen JH make critical revisions to important knowledge content; all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Yiwu Central Hospital (No. K2025-IRB-042).
Informed consent statement: The Ethics Committee agreed to waive informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Hui Chen, MD, Doctor, Department of Blood Transfusion, Yiwu Central Hospital, No. 699 Jiangdong Road, No. 519 Nanmen Street, Yiwu 322000, Zhejiang Province, China. chen_jh001@126.com
Received: July 22, 2025 Revised: August 22, 2025 Accepted: September 26, 2025 Published online: October 21, 2025 Processing time: 91 Days and 1.3 Hours
Abstract
BACKGROUND
Perioperative blood transfusion is common in gastric cancer surgery, yet its impact on postoperative inflammation, stress response, and long-term prognosis remains incompletely understood.
AIM
To investigate the effect of perioperative blood transfusion on postoperative inflammation and stress markers, as well as its correlation with prognosis in patients with gastric cancer undergoing radical gastrectomy.
METHODS
A retrospective analysis was conducted on 200 patients who underwent gastric cancer surgery, divided into a non-transfusion group (n = 108) and a transfusion group (n = 92). Baseline characteristics, pathological features, postoperative inflammatory and stress markers, complications, and long-term survival were compared between the two groups. Statistical analyses were performed using t-tests,χ2 tests, and multivariate Cox regression analysis.
RESULTS
The transfusion group had a lower T-stage distribution and higher intraoperative blood loss than the non-transfusion group (P < 0.05). Postoperative inflammatory markers such as white blood cell count, neutrophil/lymphocyte ratio, C-reactive protein, interleukin-6, and stress markers like cortisol and adrenaline were significantly higher in the transfusion group than in the non-transfusion group (P < 0.05). The incidence of postoperative complications was also higher in the transfusion group than in the non-transfusion group. Overall survival (OS) and disease-free survival (DFS) were significantly shorter in the transfusion group (P < 0.05) than in the non-transfusion group. Multivariate Cox regression analysis showed that transfusion had a negative impact on OS and DFS.
CONCLUSION
Perioperative blood transfusion is associated with increased postoperative inflammation, stress reactions, complication rates, and adverse prognosis in patients with gastric cancer. Reducing unnecessary transfusions can improve postoperative recovery and long-term prognosis.
Core Tip: This study aimed to investigate the impact of blood transfusion on postoperative inflammation and stress markers in gastric cancer patients undergoing radical gastrectomy, and its correlation with prognosis. Perioperative blood transfusion is associated with increased postoperative inflammation, stress reactions, complication rates, and adverse prognosis in gastric cancer patients. Reducing unnecessary transfusions can improve postoperative recovery and long-term prognosis.
