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Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2025; 31(38): 110645
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.110645
Immunoglobulin G4-related disease requiring clinical attention: A case report and review of literature
Ming-Li Yin, Guo-Dong Ma, Yan-Qing Gan, Peng Li, Zai-Dong Zhang, Shu-Bin Zhang, Qiang Meng, Biao Liu, Shou-Ye Zhao
Ming-Li Yin, Guo-Dong Ma, Peng Li, Zai-Dong Zhang, Qiang Meng, Biao Liu, Shou-Ye Zhao, Department of Hepatobiliary Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining 272000, Shandong Province, China
Yan-Qing Gan, Department of Cardiac Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining 272000, Shandong Province, China
Shu-Bin Zhang, Department of Surgical, Sishui County Maternal and Child Health Family Planning Service Center, Jining 273200, Shandong Province, China
Co-first authors: Ming-Li Yin and Guo-Dong Ma.
Author contributions: Yin ML and Ma GD were responsible for patient management, treatment, manuscript drafting, and data curation; Gan YQ and Zhang SB were in charge of data management and literature retrieval; Li P, Zhang ZD, Meng Q and Liu B participated in the entire treatment process of the patients; Zhao SY supervised the overall therapeutic strategy and manuscript review; All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of Shandong Province, No. ZR2019QH008.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shou-Ye Zhao, MM, Doctor, Department of Hepatobiliary Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, No. 89 Guhuai Road, Jining 272000, Shandong Province, China. zhaoshouye@mail.jnmc.edu.cn
Received: June 24, 2025
Revised: July 27, 2025
Accepted: September 3, 2025
Published online: October 14, 2025
Processing time: 113 Days and 6.2 Hours
Core Tip

Core Tip: This article describes a case of immunoglobulin G4 (IgG4)-related cholecystitis (IgG4-CC) in a patient who presented solely with abdominal pain, no pancreatic or biliary duct involvement was evident. Such an isolated occurrence of IgG4-CC is rare because IgG4-CC represents only one manifestation of IgG4-related disease (IgG4-RD). The clinical presentation of IgG4-RD is complex and highly variable, potentially affecting single or multiple organs and tissues, which increases the risks of misdiagnosis and missed diagnosis in clinical practice. For hepatobiliary and pancreatic surgeons, greater awareness of IgG4-RD is essential to avoid unnecessary surgical interventions.