Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2025; 31(37): 110164
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.110164
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.110164
Era of metabolic dysfunction-associated steatotic liver disease and impact on the liver donor pool
Juanita Pérez-Escobar, Paulina Carpinteyro-Espin, Department of Transplantation, Hospital Juárez de México, Mexico City 07760, Mexico
Aline Huerta-Álvarez, Department of Nutrition, Hospital Juárez de México, Mexico City 07760, Mexico
Graciela Elia Castro-Narro, Hepatology and Transplant Unit, Hospital Médica Sur, Mexico City 14050, Mexico
Graciela Elia Castro-Narro, Department of Gastroenterology, Hepatology and Transplant, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
María Isabel Astudillo-Delgado, Department of Gastroenterology, Hospital Juárez de México, Mexico City 07760, Mexico
Author contributions: Pérez-Escobar J, Huerta-Álvarez A, Castro-Narro GE, and Carpinteyro-Espin P conceptualized the study; Pérez-Escobar J, Huerta-Álvarez A, and Carpinteyro-Espin P revised the subsequent versions; Pérez-Escobar J and Carpinteyro-Espin P generated the figures and tables; all authors performed the investigation, wrote the first draft, and agreed to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Paulina Carpinteyro-Espin, MD, Professor, Researcher, Department of Transplantation, Hospital Juárez de México, Avenue Instituto Politécnico Nacional 5160, Mexico City 07760, Mexico. paucarpi@gmail.com
Received: June 3, 2025
Revised: July 7, 2025
Accepted: August 29, 2025
Published online: October 7, 2025
Processing time: 117 Days and 21.2 Hours
Revised: July 7, 2025
Accepted: August 29, 2025
Published online: October 7, 2025
Processing time: 117 Days and 21.2 Hours
Core Tip
Core Tip: Metabolic dysfunction-associated steatotic liver disease has been associated with a decline in the quality of available donor organs. Evaluation of liver graft steatosis is crucial for optimizing the donor pool. To maximize transplant success, decision-making algorithms need to be established, taking into account the degree of steatosis, donor characteristics, ischemia time, and recipient variables. New technologies and artificial intelligence represent future valuable tools.