WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma: Role of Calculus bovis

doi:10.3748/wjg.v31.i3.99983

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 31, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (202)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

HTML

136

Sum=143

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=44

Jan 21, 2025 (publication date) through Jan 11, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Jan 21, 2025; 31(3): 99983
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.99983

WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma: Role of Calculus bovis

Tryfonas Mpektsis, Anastasios Manolakis, Andreas Kapsoritakis

Tryfonas Mpektsis, Anastasios Manolakis, Andreas Kapsoritakis, Department of Gastroenterology, University Hospital of Larisa, Larisa 41100, Greece

Co-first authors: Tryfonas Mpektsis and Anastasios Manolakis.

Author contributions: Mpektsis T and Manolakis A participated equally in the conception, drafting, revision, and editing of the manuscript; Kapsoritakis A supervised and contributed to the drafting, revision, and language editing of the manuscript; All authors read and approved the final version of the manuscript.

Conflict-of-interest statement: The authors have nothing to disclose.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Anastasios Manolakis, MD, PhD, Assistant Professor, Department of Gastroenterology, University Hospital of Larisa, Mezourlo, Larisa 41100, Greece. manolakis@uth.gr

Received: August 4, 2024
Revised: September 29, 2024
Accepted: November 18, 2024
Published online: January 21, 2025
Processing time: 137 Days and 14.2 Hours

Core Tip

Core Tip: Activation of the WNT/β-catenin pathway plays an important role in hepatocellular carcinoma (HCC) development and the modulation of the tumor microenvironment through M2 macrophage production. Calculus bovis (CB), an herb used in traditional Chinese medicine, exhibits liver anti-tumor properties: Inhibition of the WNT/β-catenin pathway and subsequent decrease in M2 tumor-associated macrophages polarization. In all, the inhibition of WNT/β-catenin pathway emerges as a therapeutic target while the use of CB surfaces as potential medium to achieve this kind of modulation. CB, therefore, appears to be a lucrative candidate that can aid in the pharmacotherapy of HCC.