Additional considerations on a combination of inflammatory markers and scoring systems for early severity stratification of acute pancreatitis

doi:10.3748/wjg.v31.i25.108943

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Jul 7, 2025 (publication date) through Jul 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Jul 7, 2025; 31(25): 108943
Published online Jul 7, 2025. doi: 10.3748/wjg.v31.i25.108943

Additional considerations on a combination of inflammatory markers and scoring systems for early severity stratification of acute pancreatitis

Chen-Huan Wang, Ya-Qi Zhai

Chen-Huan Wang, Ya-Qi Zhai, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Author contributions: Wang CH and Zhai YQ wrote this manuscript; Zhai YQ edited the manuscript.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ya-Qi Zhai, MD, PhD, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. astaring@163.com

Received: April 27, 2025
Revised: May 16, 2025
Accepted: June 13, 2025
Published online: July 7, 2025
Processing time: 69 Days and 18.6 Hours

Core Tip

Core Tip: A novel combination of hematological parameters and scoring systems demonstrated excellent predictive performance for severe acute pancreatitis. Despite its promise, limitations—including the absence of key inflammatory markers (e.g., procalcitonin) and the need for calibration analysis, as well as practical implementation challenges—necessitate further validation and incorporation of additional variables to enhance clinical applicability.