Wang CH, Zhai YQ. Additional considerations on a combination of inflammatory markers and scoring systems for early severity stratification of acute pancreatitis. World J Gastroenterol 2025; 31(25): 108943 [DOI: 10.3748/wjg.v31.i25.108943]
Corresponding Author of This Article
Ya-Qi Zhai, MD, PhD, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. astaring@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 7, 2025; 31(25): 108943 Published online Jul 7, 2025. doi: 10.3748/wjg.v31.i25.108943
Additional considerations on a combination of inflammatory markers and scoring systems for early severity stratification of acute pancreatitis
Chen-Huan Wang, Ya-Qi Zhai
Chen-Huan Wang, Ya-Qi Zhai, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Wang CH and Zhai YQ wrote this manuscript; Zhai YQ edited the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Qi Zhai, MD, PhD, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. astaring@163.com
Received: April 27, 2025 Revised: May 16, 2025 Accepted: June 13, 2025 Published online: July 7, 2025 Processing time: 69 Days and 18.6 Hours
Abstract
A recent single-center retrospective study proposed novel combinations of hematological parameters and scoring systems for predicting severe acute pancreatitis. While these combinations showed promising predictive performance, several limitations warrant consideration, including the lack of calibration, the absence of key inflammatory markers such as procalcitonin, and practical challenges in integrating these models into routine clinical workflows. To improve predictive accuracy and clinical applicability, prospective validation and the inclusion of additional variables are recommended.
Core Tip: A novel combination of hematological parameters and scoring systems demonstrated excellent predictive performance for severe acute pancreatitis. Despite its promise, limitations—including the absence of key inflammatory markers (e.g., procalcitonin) and the need for calibration analysis, as well as practical implementation challenges—necessitate further validation and incorporation of additional variables to enhance clinical applicability.
