Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, Ding SY. Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China. World J Gastroenterol 2024; 30(10): 1346-1357 [PMID: 38596503 DOI: 10.3748/wjg.v30.i10.1346]
Corresponding Author of This Article
Su-Ying Ding, MD, Director, Doctor, Health Management Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Longhu Middle Ring Road, Jinshui District, Zhengzhou 450052, Henan Province, China. fccdingsy@zzu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
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Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, Ding SY. Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China. World J Gastroenterol 2024; 30(10): 1346-1357 [PMID: 38596503 DOI: 10.3748/wjg.v30.i10.1346]
World J Gastroenterol. Mar 14, 2024; 30(10): 1346-1357 Published online Mar 14, 2024. doi: 10.3748/wjg.v30.i10.1346
Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China
Jing-Feng Chen, Hao-Shuang Liu, Su Yan, Xiao-Qin Song, Su-Ying Ding, Health Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zhuo-Qing Wu, Institute of Systems Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, China
You-Xiang Wang, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Miao Xing, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Author contributions: Chen JF and Ding SY designed the study and acquired funding; Chen JF and Wu ZQ were responsible for developing the methodology; Yan S and Wang YX participated in the formal analysis and investigation; Chen JF wrote the original draft; Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, and Ding SY participated in the review and editing.
Supported byNational Natural Science Foundation of China, No. 72101236; China Postdoctoral Science Foundation, No. 2022M722900; Collaborative Innovation Project of Zhengzhou City, No. XTCX2023006; and Nursing Team Project of the First Affiliated Hospital of Zhengzhou University, No. HLKY2023005.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of Zhengzhou University (Approval No. 2020-KY-381).
Informed consent statement: Signed informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Su-Ying Ding, MD, Director, Doctor, Health Management Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Longhu Middle Ring Road, Jinshui District, Zhengzhou 450052, Henan Province, China. fccdingsy@zzu.edu.cn
Received: November 7, 2023 Peer-review started: November 7, 2023 First decision: December 27, 2023 Revised: January 12, 2024 Accepted: February 18, 2024 Article in press: February 18, 2024 Published online: March 14, 2024 Processing time: 128 Days and 2.7 Hours
Core Tip
Core Tip: Limited evidence exists regarding the association between persistently elevated high-normal alanine transaminase (ALT) levels and the risk of new-onset metabolic dysfunction-associated fatty liver disease (MAFLD). This cohort study analysed 3553 participants followed for four consecutive health examinations between 2017 and 2020 and measured the cumulative effects of excess high-normal ALT (ehALT). Among the participants, the incidence rate of MAFLD showed a linear increasing trend for the cumulative ehALT group. The hazard ratios of new-onset MAFLD were significantly increased in the third and fourth quartiles of the equally and unequally weighted cumulative effects of ehALT. Among Chinese adults, long-term high-normal ALT levels were related to a cumulative increased risk of new-onset MAFLD.
