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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2020; 26(7): 717-724
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.717
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.717
Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation
Yi-Chao Zhang, Bao-Xiang Chen, Xiao-Yu Xie, Yan Zhou, Qun Qian, Cong-Qing Jiang, Department of Colorectal and Anal Surgery of Zhongnan Hospital of Wuhan University, Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Hubei Key Laboratory of Intestinal and Colorectal Diseases (Zhongnan Hospital of Wuhan University), Colorectal and Anal Disease Research Center of Medical School (Zhongnan Hospital of Wuhan University), Quality Control Center of Colorectal and Anal Surgery of Health Commission of Hubei Province, Wuhan 430071, Hubei Province, China
Author contributions: Zhang YC and Chen BX contributed equally to this work; Xie XY and Zhou Y collected the clinical tissues after surgery; Qian Q coordinated the research; Jiang CQ designed and coordinated the research.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Zhongnan Hospital of Wuhan University.
Conflict-of-interest statement: The authors declare no financial conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cong-Qing Jiang, PhD, Professor, Surgeon, Department of Colorectal and Anal Surgery of Zhongnan Hospital of Wuhan University, No. 169, East Lake Road, Wuchang District, Wuhan 430071, Hubei Province, China. wb002554@whu.edu.cn
Received: November 18, 2019
Peer-review started: November 18, 2019
First decision: December 23, 2019
Revised: January 7, 2020
Accepted: January 11, 2020
Article in press: January 11, 2020
Published online: February 21, 2020
Processing time: 94 Days and 18.6 Hours
Peer-review started: November 18, 2019
First decision: December 23, 2019
Revised: January 7, 2020
Accepted: January 11, 2020
Article in press: January 11, 2020
Published online: February 21, 2020
Processing time: 94 Days and 18.6 Hours
Core Tip
Core tip: The extracellular matrix protein Tenascin-X may activate the TGF-β/Smad signaling pathway by upregulating the Smad2/3 signaling protein and thereby induce slight or complete epithelial stromal cell transformation, leading to an abnormal distribution and dysfunction of interstitial cells of Cajal in the diseased colon, which promotes the occurrence and development of slow transit constipation.