Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2020; 26(46): 7338-7351
Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7338
Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients
Guo-Hua Li, Shi-Jia Huang, Xiang Li, Xiao-Song Liu, Qiao-Ling Du
Guo-Hua Li, Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China
Shi-Jia Huang, Xiang Li, Xiao-Song Liu, Qiao-Ling Du, Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China
Author contributions: Du QL and Li GH proposed and designed the study; Li X, Liu XS and Huang SJ collected data; Li GH and Huang SJ analyzed and interpreted data; Li GH drafted the manuscript; Du QL and Huang SJ reviewed and edited the manuscript; Du QL provided administrative support and funding acquisition; All authors read, revised and approved the final draft.
Supported by the Technology Project of Shanghai Pudong New District Health and Family Planning Commission, No. PW2019D-9.
Institutional review board statement: This study was approved by the Ethics Committee of Shanghai First Maternity and Infant Health Hospital (KS2035).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The raw sequencing data have been submitted to the NCBI Sequence Read Archive under accession number PRJNA657645.
STROBE statement: The manuscript has been prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qiao-Ling Du, PhD, Doctor, Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No. 2699 West Gaoke Road, Shanghai 200040, China. qldu2004@126.com
Received: September 9, 2020
Peer-review started: September 9, 2020
First decision: September 29, 2020
Revised: October 9, 2020
Accepted: November 4, 2020
Article in press: November 4, 2020
Published online: December 14, 2020
Processing time: 95 Days and 23.6 Hours
Core Tip

Core Tip: This study is the first to investigate the consequences of intrahepatic cholestasis in pregnancy (ICP) with respect to the serum metabolome and gut microbiota. Our data suggest that ICP can cause significant changes in the serum metabolome. Changes in the relative abundance of bile acid-related compounds in serum due to ICP may have an impact on gut microbiota, which in turn may threaten the safety of pregnant women and fetuses. Our findings also suggest a mechanism of ICP that is associated with the microbiota via changes in serum metabolites.