Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2017; 23(48): 8570-8581
Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8570
Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment
Sheng-Xuan Liu, Yin-Hu Li, Wen-Kui Dai, Xue-Song Li, Chuang-Zhao Qiu, Meng-Ling Ruan, Biao Zou, Chen Dong, Yan-Hong Liu, Jia-Yi He, Zhi-Hua Huang, Sai-Nan Shu
Sheng-Xuan Liu, Xue-Song Li, Meng-Ling Ruan, Biao Zou, Chen Dong, Jia-Yi He, Zhi-Hua Huang, Sai-Nan Shu, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Yin-Hu Li, Chuang-Zhao Qiu, Yan-Hong Liu, Department of Microbial Research, WeHealthGene Institute, Shenzhen 518000, Guangdong Province, China
Wen-Kui Dai, Department of Computer Science, College of Science and Engineering, City University of Hong Kong, Hong Kong, China
Author contributions: Liu SX and Li YH contributed equally to this work; Shu SN and Huang ZH designed the research; Dai WK designed the follow-up plans and collected patients’ information with Li XS, Ruan ML, Zou B and Dong C after FMT; Qiu CZ, Liu YH and He JY performed bioinformatics analysis; Ruan ML and Zou B recorded patients’ and donors’ clinical data; Shu SN and Huang ZH conducted FMT.
Supported by National Clinical Key Specialty Construction Project (Pediatric Digestive Disease), No. [2011]873.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (IRB ID: TJ-C20140712).
Informed consent statement: All studied participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sai-Nan Shu, MD, PhD, Associate Professor, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Road, Wuhan 430030, Hubei Province, China. snshu@tjh.tjmu.edu.cn
Telephone: +86-27-83662688 Fax: +86-27-83662640
Received: September 5, 2017
Peer-review started: September 5, 2017
First decision: September 27, 2017
Revised: November 2, 2017
Accepted: November 8, 2017
Article in press: November 8, 2017
Published online: December 28, 2017
Processing time: 114 Days and 2.6 Hours
Core Tip

Core tip: This retrospective study explored the therapeutic effects and safety of fecal microbiota transplantation (FMT) treatment in 19 allergic colitis (AC) infants who were younger than 1 year old. After FMT treatment, AC symptoms were relieved in the patients rapidly, and no patient relapsed within 15 mo. With gut microbiota (GM) analysis, six of ten patients exhibited higher microbial diversity after FMT treatment. Moreover, decreased Proteobacteria and increased Firmicutes supplied the hints of GM re-establishment in the patients after FMT treatment. Therefore, this work showed the curative effects of FMT in AC infants and its possible mechanism.