Randomized Controlled Trial
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2017; 23(34): 6350-6356
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6350
Randomized controlled trial of uncut Roux-en-Y vs Billroth II reconstruction after distal gastrectomy for gastric cancer: Which technique is better for avoiding biliary reflux and gastritis?
Dong Yang, Liang He, Wei-Hua Tong, Zhi-Fang Jia, Tong-Rong Su, Quan Wang
Dong Yang, Liang He, Wei-Hua Tong, Tong-Rong Su, Quan Wang, Department of Gastrointestinal and Anal Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Zhi-Fang Jia, Division of Clinical Research, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Yang D and Wang Q designed the research; Yang D, He L and Wang Q performed the research; Yang D, Tong WH and Su TR collected the clinical data; Yang D and Jia ZF analyzed the data; Yang D, He L and Wang Q wrote the paper.
Institutional review board statement: This study was evaluated and approved by the ethics committee at our institution.
Clinical trial registration statement: This study is registered at clinicaltrials.gov. The registration identification number is NCT02694081.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at 18844097668@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Quan Wang, PhD, Professor, Surgeon, Department of Gastrointestinal and Anal Surgery, the First Hospital of Jilin University, No. 71, Xinmin Street, Changchun 130021, Jilin Province, China. wquan@jlu.edu.cn
Telephone: +86-431-81875602 Fax: +86-431-81875602
Received: June 6, 2017
Peer-review started: June 18, 2017
First decision: June 26, 2017
Revised: July 8, 2017
Accepted: August 8, 2017
Article in press: August 8, 2017
Published online: September 14, 2017
Processing time: 89 Days and 18.7 Hours
Core Tip

Core tip: Because of the challenge of recanalization, the uncut Roux-en-Y reconstruction is still controversial and needs further study. This study is the first randomized controlled trial concentrating on uncut Roux-en-Y vs Billroth II reconstruction after distal gastrectomy for gastric cancer. This study aimed to compare uncut Roux-en-Y and Billroth II reconstruction in terms of postoperative complications, including biliary reflux and gastritis. Despite the incidence of recanalization, uncut Roux-en-Y reconstruction is secure and feasible, and can effectively reduce the incidence of alkaline reflux, residual gastritis, and heartburn.