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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2017; 23(1): 87-92
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.87
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.87
Hydrogen sulfide attenuates gastric mucosal injury induced by restraint water-immersion stress via activation of KATP channel and NF-κB dependent pathway
Hong-Zhao Sun, Shan Zheng, Kai Lu, Feng-Tian Hou, Jie-Xue Bi, Xue-Lian Liu, Shan-Shan Wang, College of Life Science, Qi Lu Normal University, Zhangqiu 250200, Jinan, Shandong Province, China
Author contributions: Sun HZ and Zheng S contributed equally to this work; Sun HZ conceived and designed the experiments; Zheng S, Lu K, Hou FT, Bi JX, Liu XL and Wang SS performed the experiments; Sun HZ and Zheng S analyzed the data; Sun HZ contributed reagents/materials/analysis tools; Sun HZ wrote the paper.
Supported by Natural Science Foundation of Shandong Province , No. ZR2015CL016 and No. ZR2011CL012 ; and Colleges and Universities of Shandong Province Science and Technology Plan Projects , No. J11LC17 .
Institutional review board statement: The study was reviewed and approved by the Qi Lu Normal University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Qi Lu Normal University (IACUC protocol No. 14276).
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hong-Zhao Sun, Associate Professor, College of Life Science, Qi Lu Normal University, No. 2, Wenbo Road, Zhangqiu 250200, Jinan, Shandong Province, China. sunhongzhao18@126.com
Telephone: +86-531-66778211 Fax: +86-531-66778037
Received: August 16, 2016
Peer-review started: August 16, 2016
First decision: October 11, 2016
Revised: October 19, 2016
Accepted: November 15, 2016
Article in press: November 16, 2016
Published online: January 7, 2017
Processing time: 142 Days and 7.2 Hours
Peer-review started: August 16, 2016
First decision: October 11, 2016
Revised: October 19, 2016
Accepted: November 15, 2016
Article in press: November 16, 2016
Published online: January 7, 2017
Processing time: 142 Days and 7.2 Hours
Core Tip
Core tip: In this study, the authors demonstrate that exogenous hydrogen sulfide plays a protective role against restraint water-immersion stress injury in rats possibly through modulation of adenosine triphosphate-sensitive potassium channel opening and the nuclear factor kappa-light-chain-enhancer of activated B cells dependent pathway.