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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2015; 21(33): 9785-9792
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9785
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9785
Diffusion-weighted magnetic resonance imaging without bowel preparation for detection of ulcerative colitis
Li-Li Yu, Hai-Shan Yang, Bu-Tian Zhang, Zhong-Wen Lv, Fu-Rong Wang, Chun-Yu Zhang, Department of Radiology, The China-Japan Union Hospital of Jilin University, Changchun 130021, Jilin Province, China
Wei-Bo Chen, Philips Healthcare, Shanghai 200070, China
Hui-Mao Zhang, Department of Radiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Yu LL conceived of the study, participated in design and coordination, acquisition of data, analysis and interpretation of data, and helped to draft the manuscript; Yang HS and Zhang HM conceived of the study and reviewed radiological images; Zhang BT performed the statistical analysis; Zhang CY communicated with patients and endoscopists; Lv ZW and Wang FR participated in the MR scan; Chen WB participated in the design of MR imaging protocol.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hui-Mao Zhang, MD, PhD, Department of Radiology, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. yulili999@163.com
Telephone: +86-431-84995143 Fax: +86-431-88783300
Received: November 30, 2014
Peer-review started: November 30, 2014
First decision: January 8, 2015
Revised: February 6, 2015
Accepted: March 31, 2015
Article in press: March 31, 2015
Published online: September 7, 2015
Processing time: 280 Days and 21.2 Hours
Peer-review started: November 30, 2014
First decision: January 8, 2015
Revised: February 6, 2015
Accepted: March 31, 2015
Article in press: March 31, 2015
Published online: September 7, 2015
Processing time: 280 Days and 21.2 Hours
Core Tip
Core tip: Our results indicated that diffusion-weighted imaging (DWI) provides qualitative and quantitative information when this technique is combined with conventional magnetic resonance imaging without bowel preparation; the combined technique demonstrates a good diagnostic performance to detect colonic inflammation in ulcerative colitis. This technique is completely non-invasive, does not apply ionizing radiation or contrast material injection, does not require any bowel preparation and does not cause discomfort to patients. The optimal b value is 800 s/mm2. DWI hyperintensity at b = 800 s/mm2 detected endoscopic colonic inflammation with a sensitivity of 93.0% and a specificity of 79.3%.