Mori H, Kobara H, Nishiyama N, Masaki T. Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet. World J Gastroenterol 2018; 24(2): 211-215 [PMID: 29375206 DOI: 10.3748/wjg.v24.i2.211]
Corresponding Author of This Article
Hirohito Mori, MD, PhD, Associate Professor, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. hiro4884@med.kagawa-u.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Mori H, Kobara H, Nishiyama N, Masaki T. Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet. World J Gastroenterol 2018; 24(2): 211-215 [PMID: 29375206 DOI: 10.3748/wjg.v24.i2.211]
Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Tsutomu Masaki, Departments of Gastroenterology and Neurology, Kagawa University, Kagawa 761-0793, Japan
Author contributions: Mori H was responsible for devising the research and writing the manuscript; Kobara H and Nishiyama N participated equally in the work; Masaki T provided a critical revision of the manuscript for intellectual content and was responsible for final approval of the manuscript.
Supported by The Translational Research Program and the Strategic Promotion for Practical Applications of Innovative Medical Technology (TR-SPRINT) from the Japan Agency for Medical Research and Development (AMED).
Institutional review board statement: This Animal experiment was approved by Animal Laboratory Regulations of Kagawa University according to the Regulations and Guidelines of animal experiment of Kagawa University. [See the supplement PDF file of Institutional Review Board Approval Form (Approval No: A34) of Kagawa University].
Institutional animal care and use committee statement: Animal experiments were performed based on Preclinical Animal Laboratory of Kagawa University according to the guidelines of animals by Kagawa University.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest, and no corporate financing was received.
Data sharing statement: Technical procedures and dataset are available from the corresponding author at [hiro4884@med.kagawa-u.ac.jp].
Correspondence to: Hirohito Mori, MD, PhD, Associate Professor, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. hiro4884@med.kagawa-u.ac.jp
Telephone: +81-87-891-2156 Fax: +81-87-891-2158
Received: November 6, 2017 Peer-review started: November 7, 2017 First decision: November 14, 2017 Revised: November 27, 2017 Accepted: December 5, 2017 Article in press: December 5, 2017 Published online: January 14, 2018 Processing time: 68 Days and 11.8 Hours
ARTICLE HIGHLIGHTS
Research background
Post-Endoscopic submucosal dissections (ESD) bleeding is one of crucial adverse events for patients who take anti-thrombotic agents.
Research motivation
Although there were several reports with regard to polyglycolic acid sheet (PGAs) to prevent post-ESD bleeding, it is difficult to deliver and cover the post-ESD ulcer floor with PGAs. Developing new measurement or device to deliver PGAs is necessary to perform safer ESD.
Research objectives
To evaluate the efficacy of appropriate and rapid PGAs delivery method using innovative device delivery station system (DDSS).
Research methods
Beagle dogs were used in this pilot basic study. Two ESDs 4 cm in diameter were performed (total 6 ESDs performed). Covering times of PGAs only by pan-endoscope, post ESD bleedings and perforations during ESD were investigated.
Research results
DDSS made it possible to cover post-ESD ulcer rapidly and reduce the post-ESD adverse event (bleeding of 1-7 d after ESD).
Research conclusions
DDSS was very useful for rapid delivering and tight attachment of PGAs to control post-ESD bleeding. DDSS can deliver lots of endoscopic devices and surgical materials that can be placed within the digestive tract under sealed conditions.
Research perspectives
DDSS has innovative potentials of multi-purpose device delivery measurements.
Multi-center prospective studies are needed to confirm the advantages of DDSS not only for PGAs delivery but also other endoscopic devices and materials.
