Mori H, Kobara H, Nishiyama N, Masaki T. Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet. World J Gastroenterol 2018; 24(2): 211-215 [PMID: 29375206 DOI: 10.3748/wjg.v24.i2.211]
Corresponding Author of This Article
Hirohito Mori, MD, PhD, Associate Professor, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. hiro4884@med.kagawa-u.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Mori H, Kobara H, Nishiyama N, Masaki T. Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet. World J Gastroenterol 2018; 24(2): 211-215 [PMID: 29375206 DOI: 10.3748/wjg.v24.i2.211]
Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Tsutomu Masaki, Departments of Gastroenterology and Neurology, Kagawa University, Kagawa 761-0793, Japan
Author contributions: Mori H was responsible for devising the research and writing the manuscript; Kobara H and Nishiyama N participated equally in the work; Masaki T provided a critical revision of the manuscript for intellectual content and was responsible for final approval of the manuscript.
Supported by The Translational Research Program and the Strategic Promotion for Practical Applications of Innovative Medical Technology (TR-SPRINT) from the Japan Agency for Medical Research and Development (AMED).
Institutional review board statement: This Animal experiment was approved by Animal Laboratory Regulations of Kagawa University according to the Regulations and Guidelines of animal experiment of Kagawa University. [See the supplement PDF file of Institutional Review Board Approval Form (Approval No: A34) of Kagawa University].
Institutional animal care and use committee statement: Animal experiments were performed based on Preclinical Animal Laboratory of Kagawa University according to the guidelines of animals by Kagawa University.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest, and no corporate financing was received.
Data sharing statement: Technical procedures and dataset are available from the corresponding author at [hiro4884@med.kagawa-u.ac.jp].
Correspondence to: Hirohito Mori, MD, PhD, Associate Professor, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. hiro4884@med.kagawa-u.ac.jp
Telephone: +81-87-891-2156 Fax: +81-87-891-2158
Received: November 6, 2017 Peer-review started: November 7, 2017 First decision: November 14, 2017 Revised: November 27, 2017 Accepted: December 5, 2017 Article in press: December 5, 2017 Published online: January 14, 2018 Processing time: 68 Days and 11.8 Hours
Abstract
AIM
To evaluate appropriate and rapid polyglycolic acid sheet (PGAs) covering time using device delivery station system (DDSS).
METHODS
This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-mo-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections (ESDs) 4cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum (total 6 ESDs performed). DDSS (3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P® (CSL Behring K.K., Tokyo, Japan) (combination of fibrin glue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during ESD.
RESULTS
The covering time of PGAs (defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07 (4.86-8.29) min. There was no post-ESD bleeding (1-7 d after ESD), and there was no perforation during ESD.
CONCLUSION
DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multi-purpose delivery station system.
Core tip: Although mechanical closures of larger artificial ulcer floor are effective to prevent post-endoscopic submucosal dissection (ESD) bleeding, mechanical closures might create a mucosal bridge which reduces the efficacy of prevention of post-ESD bleeding. Although covering with polyglycolic acid sheet (PGAs) is a more ideal treatment, it is difficult to deliver thin PGAs by pan-endoscope. Therefore, novel concept to deliver various devices and materials were developed.
