Raissa NJ, Yao SY, Wang F. Relationship between Helicobacter pylori infection and the development of metabolic dysfunction and associated steatotic liver disease. World J Gastroenterol 2025; 31(33): 110176 [DOI: 10.3748/wjg.v31.i33.110176]
Corresponding Author of This Article
Fen Wang, MD, Professor, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, No. 138 Tongzi Road, Changsha 410013, Hunan Province, China. wfen-judy@csu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 7, 2025; 31(33): 110176 Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.110176
Relationship between Helicobacter pylori infection and the development of metabolic dysfunction and associated steatotic liver disease
Noube Julie Raissa, Shuo-Yi Yao, Fen Wang
Noube Julie Raissa, Shuo-Yi Yao, Fen Wang, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
Co-first authors: Noube Julie Raissa and Shuo-Yi Yao.
Author contributions: Raissa NJ wrote the original draft; Yao SY reviewed and edited the article, and supervised the research; Wang F reviewed and edited the article, acquired the funding, and conceptualized and administrated the project. Raissa NJ and Yao SY contributed equally to this manuscript and are co-first authors. All authors have read and agreed to the published version of the manuscript.
Supported by National Natural Science Foundation of China, No. 82270594.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fen Wang, MD, Professor, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, No. 138 Tongzi Road, Changsha 410013, Hunan Province, China. wfen-judy@csu.edu.cn
Received: June 3, 2025 Revised: July 6, 2025 Accepted: August 13, 2025 Published online: September 7, 2025 Processing time: 92 Days and 13.5 Hours
Abstract
This research is to explore the relationship between Helicobacter pylori (H. pylori) infection and the development of metabolic dysfunction and metabolic dysfunction-associated steatotic liver disease (MASLD), based on research by Ye et al. Their investigation analyzed the association of H. pylori infection with obesity, glucose, lipids, blood pressure, and MASLD in Chinese adults, through a cross-sectional study of 28624 participants. Clinical data analysis demonstrated that H. pylori-positive participants exhibited significantly higher ages, blood glucose, total cholesterol, low-density lipoprotein, body mass index, systolic and diastolic blood pressure levels, and greater MASLD detection rates compare to the H. pylori-negative participants. These differences achieved statistical significance (P < 0.05). Multivariate analysis identified, elevated glucose, body mass index, and diastolic pressure as independent risk factors for H. pylori infection, while high-density lipoprotein demonstrated protective effects. These findings suggest that H. pylori infection may contribute to metabolic disturbances and MASLD.
Core Tip: This article discussed the relationship between Helicobacter pylori (H. pylori) and the development of metabolic dysfunction and metabolic dysfunction-associated steatotic liver disease (MASLD) based on the study by Ye et al. Their study concluded that H. pylori may play a role in metabolic disturbances (especially in parameters including blood glucose, body mass index, and diastolic blood pressure) and MASLD. There are also other studies in different populations that confirmed the association between H. pylori infection and MASLD.
