In 2016, the World Journal of Hepatology (WJH) has published the 23^rd issue which containing 5 articles contributed by scientists worldwide. Among these comprehensive articles are (1) “Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training”, a Review by Jean-Marc Lavoie, PhD, Professor, et al from Department of Kinesiology, University of Montreal, Canada; (2) “Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription”, an Original Article by Deng-Fu Yao, MD, PhD, Professor, et al from Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, China, etc. We invite you to peruse all 5 articles in this issue, as they present the latest research progress/findings and provide insightful comments in hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 8, Issue 23, August 18, 2016.

Figure 1 The cover of the issue. Editorial Board Member of World Journal of Hepatology, Oliver Ebert, MD, Attending Doctor, Ⅱ. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, D-81675 Muenchen, Germany

The WJH is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of hepatology. It was launched on October 31, 2009 and is published three issues per month (36 issues annually) by BPG, the world's leading professional clinical medical journal publishing company.

We encourage hepatologists worldwide to submit manuscripts to the WJH describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue, at: http://www.wjgnet.com/1948-5182/e-journal.htm.