In 2018, the World Journal of Gastroenterology (WJG) has published the 16^th issue which containing 9 articles including 5 reviews, 3 original articles, and 1 case report contributed by scientists worldwide. Among these comprehensive articles are (1) “Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma”, a review by Naofumi Mukaida, MD, PhD, Professor, from Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Japan; (2) “Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models”, a basic study by Kunwar Shailubhai, PhD, Professor, et al Baruch S. Blumberg Institute, United States; and (3) “Usefulness of three-dimensional visualization technology in minimally invasive treatment for infected necrotizing pancreatitis”, a retrospective study by Shou-Wang Cai, MD, PhD, Chief Doctor, et al from Department of Hepatobiliary Surgery, PLA General Hospital, China, etc. We invite you to peruse all 9 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 24, Issue 17, may 7, 2018.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology, Khaled Ali Jadallah, MD, Associate Professor, Doctor, Department of Internal Medicine, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid 22110, Jordan

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue.