In 2018, the World Journal of Gastroenterology (WJG) has published the 6^th issue which containing 11 articles including 10 original articles, and 1 case report contributed by scientists worldwide. Among these comprehensive articles are (1) “Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease”, a basic study by Saleh A Naser, PhD, Professor, Associate Director, et al from Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, United States; (2) “Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion”, a clinical practice study by Lian-Fang Du, MD, Chief Doctor, Full Professor, et al from Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China; and (3) “High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation”, an observational study by Voranush Chongsrisawat, MD, Associated Professor, Chief, et al from Division of Gastroenterology and Hepatology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand, etc. We invite you to peruse all 11 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 24, Issue 6, February 14, 2018.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology, Yoshiaki Iwasaki, MD, PhD, Professor, Health Service Center, Okayama University, Okayama 700-8530, Japan

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue.