In 2016, the World Journal of Hepatology (WJH) has published the 35^th issue which containing 7 articles contributed by scientists worldwide. Among these comprehensive articles are (1) “How to assess the efficacy or failure of targeted therapy: Deciding when to stop sorafenib in hepatocellular carcinoma”, a Minireviews by Dr. Jean-Luc Raoul, Professor, et al from Department of Medical Oncology, Paoli-Calmettes Institute, France; (2) “Hepatitis C eradication with sofosbuvir leads to significant metabolic changes”, an Original Article by Amilcar L Morales, MD, et al from San Antonio Military Medical Center, United States, etc. We invite you to peruse all 7 articles in this issue, as they present the latest research progress/findings and provide insightful comments in hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 8, Issue 35, December 18, 2016.

Figure 1 The cover of the issue. Editorial Board Member of World Journal of Hepatology, Ahmed O Kaseb, MD, Associate Professor, Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States

The WJH is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of hepatology. It was launched on October 31, 2009 and is published three issues per month (36 issues annually) by BPG, the world's leading professional clinical medical journal publishing company.

We encourage hepatologists worldwide to submit manuscripts to the WJH describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue, at: http://www.wjgnet.com/1948-5182/e-journal.htm.