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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Dec 18, 2025; 13(4): 112603
Published online Dec 18, 2025. doi: 10.13105/wjma.v13.i4.112603
Published online Dec 18, 2025. doi: 10.13105/wjma.v13.i4.112603
Clinical prognostic scores for dengue fever: A systematic review
Keerthana Thangaraja, Jun Yi Jonathan Heng, Gayathri Basker, Shu Ting Chong, Department of Medicine, Yong Loo Lin School of Medicine, Singapore 117597, Singapore
Kay Choong See, Department of Medicine, National University Hospital, Singapore 119228, Singapore
Author contributions: Thangaraja K, Heng JYJ, Basker G, Chong ST, See KC designed and performed the research; Thangaraja K, Heng JYJ, Basker G, Chong ST analysed the data and wrote the paper.
Conflict-of-interest statement: All authors declare no conflicts of interest in this paper.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Keerthana Thangaraja, Department of Medicine, Yong Loo Lin School of Medicine, 10 Medical Dr, Singapore 117597, Singapore. thangaraja.keerthana@u.nus.edu
Received: August 1, 2025
Revised: August 22, 2025
Accepted: December 5, 2025
Published online: December 18, 2025
Processing time: 139 Days and 21.6 Hours
Revised: August 22, 2025
Accepted: December 5, 2025
Published online: December 18, 2025
Processing time: 139 Days and 21.6 Hours
Core Tip
Core Tip: This is a comprehensive systematic review to evaluate and compare the accuracy of prognostic models in both adult and paediatric populations with dengue fever. Out of 29 included studies comprising over 17000 patients, we highlight models that demonstrated high specificity and sensitivity. Notably, the Bedside Dengue Severity Score by Gayathri et al and the nomogram by Nguyen et al performed best among paediatric models, while Leo et al’s and Lee et al’s models showed outstanding performance in adult populations. This nuanced breakdown by demographic and model performance offers actionable insights not previously synthesized in the literature.