Published online Jun 28, 2021. doi: 10.13105/wjma.v9.i3.309
Peer-review started: April 23, 2021
First decision: May 19, 2021
Revised: May 24, 2021
Accepted: June 17, 2021
Article in press: June 17, 2021
Published online: June 28, 2021
Processing time: 79 Days and 15.5 Hours
Psoriasis is a multifactorial autoimmune disease, and it has been suggested that bacterial infection can contribute to the initiation or development of this disease.
We performed this study to discover the association between infection with Streptococcus pyogenes (S. pyogenes) as potential factors and risk of develop to psoriasis.
The objective of this study was to determine the impact of S. pyogenes infection and susceptibility to psoriasis using available case-control studies.
We used a computer-assisted comprehensive literature search to obtain relevant case-control regarding to the possible connection between S. pyogenes infection and psoriasis. Finally, the impact of infection with S. pyogenes and susceptibility to psoriasis was measured using odds ratio (OR) with 95% confidence intervals (CIs).
The rate of infection with S. pyogenes in psoriatic patients vs healthy individuals was 33.4% and 16.2%, respectively. Furthermore, there is a significant association between S. pyogenes infection and development of psoriasis (OR: 6.58; 95%CI: 3.64-11.87; P = 0.001)
Infection with S. pyogenes is a risk factor for susceptibility to psoriasis.
Further long-term cohort studies are needed to investigate the relationship between S. pyogenes infection and psoriasis. Also, studies are needed to evaluate the clinical efficacy of the treatment of S. pyogenes infection in decreasing the number of psoriatic events.