da Silva FRP, Leal ALAB, Galeno JG, Monteiro AVO, Araujo FAH, de Oliveira Tavares K, Souza Monteiro JR, de Oliveira ACA, Pereira AL, da Cunha Pereira ACT, Vasconcelos DFP. Association of the rs1333048 polymorphism in the ANRIL gene with different clinical forms of periodontitis: A meta-analysis. World J Meta-Anal 2025; 13(4): 108504 [DOI: 10.13105/wjma.v13.i4.108504]
Corresponding Author of This Article
Adenilson Leão Pereira, Professor, Medicine College, Federal University of Para, Altamira 68372-040, Pará, Brazil. adenilsonlp@ufpa.br
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Meta-Analysis
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 18, 2025 (publication date) through Jan 7, 2026
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Publication Name
World Journal of Meta-Analysis
ISSN
2308-3840
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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da Silva FRP, Leal ALAB, Galeno JG, Monteiro AVO, Araujo FAH, de Oliveira Tavares K, Souza Monteiro JR, de Oliveira ACA, Pereira AL, da Cunha Pereira ACT, Vasconcelos DFP. Association of the rs1333048 polymorphism in the ANRIL gene with different clinical forms of periodontitis: A meta-analysis. World J Meta-Anal 2025; 13(4): 108504 [DOI: 10.13105/wjma.v13.i4.108504]
World J Meta-Anal. Dec 18, 2025; 13(4): 108504 Published online Dec 18, 2025. doi: 10.13105/wjma.v13.i4.108504
Association of the rs1333048 polymorphism in the ANRIL gene with different clinical forms of periodontitis: A meta-analysis
Felipe Rodolfo Pereira da Silva, Alessandro Luiz Araújo Bentes Leal, Juliana Gomes Galeno, André Victor Oliveira Monteiro, Francisco Angelis Herrera Araujo, Kamilly de Oliveira Tavares, José Rogério Souza Monteiro, Ana Carolina Alves de Oliveira, Adenilson Leão Pereira, Anna Carolina Toledo da Cunha Pereira, Daniel Fernando Pereira Vasconcelos
Felipe Rodolfo Pereira da Silva, André Victor Oliveira Monteiro, Medicine College, Federal University Para, Altamira 68373-106, Pará, Brazil
Alessandro Luiz Araújo Bentes Leal, José Rogério Souza Monteiro, Ana Carolina Alves de Oliveira, Adenilson Leão Pereira, Medicine College, Federal University of Para, Altamira 68372-040, Pará, Brazil
Juliana Gomes Galeno, Anna Carolina Toledo da Cunha Pereira, Daniel Fernando Pereira Vasconcelos, Department of Biomedicine, Parnaiba Delta Federal University, Parnaiba 64202-020, Piauí, Brazil
Francisco Angelis Herrera Araujo, Kamilly de Oliveira Tavares, Department of Pharmacy, Serra Dourada College, Altamira 68378-001, Pará, Brazil
Author contributions: Da Silva FRP and Vasconcelos DFP contributed to the study design; da Silva FRP and Leal ALAB contributed to data collection; da Silva FRP and Galeno JG contributed to statistical analyses; da Silva FRP, Araujo FAH, Tavares KO, and Monteiro AVO contributed to data interpretation; da Silva FRP, Monteiro JRS, de Oliveira ACA, Pereira AL, Monteiro AVO, and Pereira ACTC contributed to manuscript preparation of the manuscript; da Silva FRP contributed to the literature search.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Adenilson Leão Pereira, Professor, Medicine College, Federal University of Para, Altamira 68372-040, Pará, Brazil. adenilsonlp@ufpa.br
Received: April 16, 2025 Revised: May 16, 2025 Accepted: September 18, 2025 Published online: December 18, 2025 Processing time: 246 Days and 16.9 Hours
Abstract
BACKGROUND
Periodontitis is a chronic inflammatory disorder influenced by both behavioral and genetic factors. Among epigenetic regulators, the ANRIL gene has been proposed as a risk factor for periodontitis; however, findings on the association between ANRIL polymorphisms and disease susceptibility remain inconsistent.
AIM
To analyze the association between the rs1333048 genetic polymorphism in the ANRIL gene and periodontitis via meta-analysis.
METHODS
A literature search was performed for studies published before May 2, 2025. The Review Manager statistical program was used in analyses with calculations of heterogeneity index (I²) and odds ratio (OR) with 95% of confidence intervals (CI). Begg’s test and the Egger’s linear regression test were used for publication bias evaluation using Comprehensive meta-analysis software. P < 0.05 was considered significant.
RESULTS
From 12 studies including 5489 participants across multiple ethnic groups, we observed a statistically significant association between ANRIL gene polymorphisms and periodontitis in the allelic contrast model (OR = 1.24 95%CI: 1.15-1.34, P < 0.00001). Conversely, the wild-type allele was significantly associated with the control group (OR = 0.80 95%CI: 0.75-0.87, P < 0.00001). Heterogeneity was low (I² = 28%, Pheterogeneity = 0.17), and no significant risk of publication bias was detected (P > 0.05).
CONCLUSION
In conclusion, this meta-analysis demonstrated a significant association between the rs1333048 polymorphism and periodontitis in the overall analysis and in stratified analyses of Caucasian populations, but in for mixed-race populations.
Core Tip: Many case-control studies have identified a relationship between the rs1333048 polymorphism and periodontitis. However, the impact of this genetic variation on the clinical aspect of periodontitis is still unknown.
