Gastrointestinal stromal tumor with multisegmental spinal metastases as first presentation: A case report and review of the literature

Table 1 Clinical data for 26 cases of gastrointestinal stromal tumor with spinal metastases

Patient	Age/sex	Primary tumor location	Location of metastases	Spinal metastases treatment
1[23]	62/M	Small intestine	Liver, spine, pelvis, rib	Zoledronic acid + radiotherapy + TKI
2[23]	82/F	Stomach	Liver, spine, pelvis	Zoledronic acid + TKI
3[23]	54/F	Small intestine	Liver, rib, spine, iliac bone	Zoledronic acid + TKI
4[24]	55/M	Sigmoid colon	Liver, spine, skull, pelvis	TKI + zoledronic acid
5[22]	56/M	Esophagus	Spine, rib	TKI + zoledronic acid
6[25]	49/M	Stomach	Liver, spleen, peritoneum, soft tissue, spine, rib, pelvis, femur, humerus	TKI
7[25]	52/F	Stomach	Liver, spleen, spine, rib, pelvis	TKI
8[25]	48/M	Stomach	Liver, spleen, spine	TKI
9[25]	51/M	Stomach	Liver, spleen, soft tissue, rib, humerus	TKI
10[25]	60/M	Small intestine	Liver, spine	TKI
11[25]	71/M	Rectum	Liver, spleen, spine, rib, pelvis, femur, humerus	TKI
12[26]	56/M	Small intestine	Liver, hip, spine, femur	TKI + radiotherapy + zoledronic acid
13[26]	70/M	Small intestine	Liver, spine	TKI + radiotherapy + zoledronic acid
14[27]	66/M	Stomach	Liver, spine, pelvis, rib, sternum, scapula	TKI
15[13]	51/M	Rectum	Spine	Resection
16[28]	69/F	Stomach	Liver, spine, subcutaneous	TKI + radiotherapy
17[29]	46/M	Stomach	Liver, spine, rib, humerus, clavicle	TKI + radiotherapy
18[30]	61/F	Stomach	Spine, liver, lung	Resection + TKI
19[30]	58/M	Small intestine	Spine, humerus, liver, peritoneum	Resection + TKI
20[30]	71/M	Small intestine	Spine, humerus, liver, pleura	Resection + TKI
21[31]	58/M	Small intestine	Liver, spine, sternoclavicular joint	TKI + radiotherapy
22[32]	37/M	Small intestine	Liver, spine	Resection + TKI + radiotherapy + chemotherapy
23[33]	54/M	Small intestine	Liver, spine	Resection + sorafenib + regorafenib
24[34]	76/F	Rectum	Spine, rib	Resection + TKI
25[21]	57/M	Rectum	Liver, lung, spine, clivus, temporal bone	TKI + radiotherapy
26[35]	83/M	Colon	Spine	Resection + radiotherapy

TKI: Tyrosine kinase receptor inhibitor.