Wu MJ, Fang QL, Zou SY, Zhu Y, Lu W, Du X, Shi BM. Influencing factors for hepatic fat accumulation in patients with type 2 diabetes mellitus. World J Clin Cases 2021; 9(26): 7717-7728 [PMID: 34621822 DOI: 10.12998/wjcc.v9.i26.7717]
Corresponding Author of This Article
Xuan Du, MD, Doctor, Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, No.188 Shizi street, Suzhou 215000, Jiangsu Province, China, cathy-dx0630@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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Table 2 Spearman correlation analysis of hepatic fat fraction with other variables
Variable
r
P value
Age
0.136
0.013
BMI
0.493
< 0.001
WHR
0.227
< 0.001
FPG
0.281
< 0.001
FINS
0.133
0.016
FCP
0.385
< 0.001
HOMA-IR
0.247
< 0.001
UA
0.305
< 0.001
ALT
0.459
< 0.001
AST
0.385
< 0.001
DBIL
0.154
0.005
IBIL
0.251
< 0.001
TBIL
0.234
< 0.001
LDH
0.126
0.022
GGT
0.413
< 0.001
ALB
0.217
< 0.001
TC
0.193
< 0.001
TG
0.478
< 0.001
LDL-C
0.269
< 0.001
HDL-C
-0.251
< 0.001
CRP
0.251
< 0.001
FT3
0.157
0.005
Table 3 Multivariate linear regression analysis of hepatic fat fraction with other variables in type 2 diabetes mellitus patients
Variable
B
SE
β
t
P value
95%CI
ALT
0.080
0.008
0.437
9.455
< 0.001
0.063-0.096
BMI
0.409
0.083
0.246
4.925
< 0.001
0.246-0.573
LDL-C
1.040
0.380
0.121
2.737
0.007
0.292-1.788
UA
0.008
0.003
0.108
2.253
0.025
0.001-0.014
ALB
0.135
0.065
0.091
2.070
0.039
0.007-0.263
Table 4 Multivariate binary logistic regression analysis of independent influencing factors for moderate to severe fatty liver in type 2 diabetes mellitus patients
Variable
B
SE
Wald
P value
OR
95%CI
BMI
< 24
24-27.99
0.830
0.329
6.361
0.012
2.294
1.203-4.373
≥ 28
1.615
0.379
18.121
< 0.001
5.027
2.390-10.572
ALT
0.028
0.007
15.643
< 0.001
1.029
1.014-1.043
ALB
0.099
0.036
7.480
0.006
1.105
1.029-1.186
LDL-C
0.537
0.185
8.389
0.004
1.710
1.189-2.459
Citation: Wu MJ, Fang QL, Zou SY, Zhu Y, Lu W, Du X, Shi BM. Influencing factors for hepatic fat accumulation in patients with type 2 diabetes mellitus. World J Clin Cases 2021; 9(26): 7717-7728