Su W, Tian XD, Liu P, Zhou DJ, Cao FL. Accuracy of endoscopic ultrasound-guided needle aspiration specimens for molecular diagnosis of non-small-cell lung carcinoma. World J Clin Cases 2020; 8(21): 5139-5148 [PMID: 33269250 DOI: 10.12998/wjcc.v8.i21.5139]
Corresponding Author of This Article
Fu-Liang Cao, MD, Attending Doctor, Department of Endoscopy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, West Huanhu Road, Ti Yuan Bei, Hexi District, Tianjin 300060, China. fuliangcao2008@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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World J Clin Cases. Nov 6, 2020; 8(21): 5139-5148 Published online Nov 6, 2020. doi: 10.12998/wjcc.v8.i21.5139
Table 1 Clinical characteristics of the 81 patients, n (%)
Characteristics
Patients, n = 81
Gender
Male
59 (72.8)
Female
22 (27.2)
Smoking status
Nonsmoker
39 (48.1)
Former or current smoker
42 (51.9)
Pathological type
Adenocarcinoma
62 (76.5)
Squamous cell carcinoma
11 (13.6)
Adenosquamous carcinoma
3 (3.7)
NSCLC-NOS
5 (6.2)
Clinical stage
IIIA
15 (18.5)
IIIB
28 (34.6)
IIIC
3 (3.7)
IV
35 (43.2)
Distant metastasis
Malignant pleural effusion
3 (3.7)
Pleura
4 (4.9)
Contralateral lung
9 (11.1)
Bone
14 (17.3)
Brain
9 (11.1)
Liver
3 (3.7)
Adrenal gland
5 (6.2)
Table 2 Puncture site and lesion size
Location of sample
Patients, n
Minimum, mm
Maximum, mm
Primary tumor
Right
18
24
65
Left
7
28
91
Lymph node
2R
2
10
21
4R
19
9
34
4L
4
27
28
5
2
19
38
7
35
15
70
8
2
12
20
10R
5
24
26
10L
3
23
45
Table 3 Puncture of multiple lesions
Location of sample
Patients, n
4R, 4L, 7
1
4R, 7
7
5, 7
1
7, 8
1
Left lung mass, 7
1
Right lung mass, 4R
2
Right lung mass, 7
2
Table 4 Molecular analysis of all patients
Adenocarcinoma, n = 62
Squamous cell carcinoma, n = 11
Adenosquamous carcinoma, n = 3
NSCLC-NOS, n = 5
EGFR mutation
Exon 19
E746-A750del (1)
2
0
0
0
E746-A750del (2)
4
0
0
0
L747-T751del
2
0
0
0
L747-S752del
1
0
0
0
L747-A750del
1
0
0
0
Exon 21
0
L858R
8
0
1
0
L861Q
2
0
0
0
KRAS mutation
Exon 2
G12C
3
1
0
0
G12D
2
0
0
0
G12V
2
0
0
0
G12L
1
0
0
0
ROS-1 (FISH) positive
1
0
0
0
ALK (Ventana IHC) positive
5
0
0
0
Table 5 Molecular analysis of patients with multiple lesions
Type
Puncture site
Mutation
Puncture site
Mutation
1
Adenocarcinoma
5
Insufficient sample
7
EGFR, exon 21 L858R
2
Adenocarcinoma
Right lung mass
EGFR, exon 21 L858R
7
EGFR, exon 21 L858R
3
Adenocarcinoma
4R
EGFR, exon 21 L858R
7
EGFR, exon 21 L858R
4
Squamous cell carcinoma
4R
KRAS, exon 2 G12C
7
KRAS, exon 2 G12C
Table 6 Response to targeted therapy
Drugs
CR, n
PR, n
SD, n
PD, n
EGFR mutation
Gefitinib, erlotinib, extinib
0
13
3
3
ROS-1 positive
Crizotinib
0
0
1
0
ALK positive
Crizotinib
0
3
0
1
Citation: Su W, Tian XD, Liu P, Zhou DJ, Cao FL. Accuracy of endoscopic ultrasound-guided needle aspiration specimens for molecular diagnosis of non-small-cell lung carcinoma. World J Clin Cases 2020; 8(21): 5139-5148