Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2020; 8(21): 5139-5148
Published online Nov 6, 2020. doi: 10.12998/wjcc.v8.i21.5139
Accuracy of endoscopic ultrasound-guided needle aspiration specimens for molecular diagnosis of non-small-cell lung carcinoma
Wei Su, Xiang-Dong Tian, Peng Liu, De-Jun Zhou, Fu-Liang Cao
Wei Su, Xiang-Dong Tian, Peng Liu, De-Jun Zhou, Fu-Liang Cao, Department of Endoscopy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
Author contributions: Su W collected and analyzed the data and wrote the paper; Tian XD collected medical record information and searched references; Liu P provided clinical advice and modified the manuscript; Zhou DJ designed the research and supervised the report; Cao FL designed the research and approved final version of paper; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81903055; and Tumor Translational Medicine Seed Fund of Tianjin Medical University Cancer Institute and Hospital, No. 1709.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Tianjin Medical University Cancer Institute and Hospital (Approval No. bc2020023).
Informed consent statement: Patients were not required to provide informed consent for this study because the analysis used anonymous clinical data that were obtained after patient had agreed to treatment with written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Liang Cao, MD, Attending Doctor, Department of Endoscopy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, West Huanhu Road, Ti Yuan Bei, Hexi District, Tianjin 300060, China. fuliangcao2008@163.com
Received: June 28, 2020
Peer-review started: June 28, 2020
First decision: July 24, 2020
Revised: August 4, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: November 6, 2020
Processing time: 131 Days and 0.1 Hours
Core Tip

Core Tip: The purpose of this retrospective study was to evaluate the feasibility and reliability of tissue samples obtained using endoscopic ultrasonography-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration for molecular diagnosis of non-small cell lung carcinoma. In the study, 93.9% of the puncture samples could be used for molecular testing. The proportion of patients with positive results corresponds to the frequency of molecular mutations. Patients receiving targeted therapy responded well to treatment. The samples obtained by the two techniques can be used for molecular diagnosis of lung cancer. They can provide reliable evidence for clinical diagnosis and treatment.