Case Report
Copyright ©The Author(s) 2020.
World J Clin Cases. Oct 26, 2020; 8(20): 4946-4952
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4946
Table 1 Diagnostic criteria for hemophagocytic lymphohistiocytosis used the hemophagocytic lymphohistiocytosis-2004 trial
Diagnostic criteria for HLH fulfilled, at least 5 of the 8 criteria belowFirst admissionPost-treatmentSecond admissionThird admission
FeverYNYY
SplenomegalyYNNN
Cytopenia, affecting 2 of 3 lineages in the peripheral bloodYNNN
Hemoglobin < 9 g/dLYNNN
Platelets < 100 × 109/LYNNN
Neutrophils < 1.0 × 109/LYNNN
Hypertriglyceridemia (fasting ≥ 3.0 mmol/L) and/or hypofibrinogenemia (≤ 150 mg/dL)YNNN
Hemophagocytosis in bone marrow or spleen or lymph nodes (no evidence of malignancy)YNANANA
Low or absent natural killer cell activityNANANANA
Ferritin ≥ 500 ng/mLYNNN
Soluble cluster of differentiation 25 (i.e. soluble interleukin 2 receptor) ≥ 2400 U/mLNANANANA