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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2020; 8(20): 4946-4952
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4946
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4946
Systemic autoimmune abnormalities complicated by cytomegalovirus-induced hemophagocytic lymphohistiocytosis: A case report
Shu-Xian Miao, Zhi-Qi Wu, Hua-Guo Xu, Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Xu HG and Wu ZQ designed the report; Miao SX collected the patient’s clinical data; All authors participated in the writing of the manuscript.
Supported by Natural Science Foundation of Jiangsu Province of China , No. BK20181492 ; the National Key Clinical Department of Laboratory Medicine of China in Nanjing , Key laboratory for Laboratory Medicine of Jiangsu Province, No. ZDXKB2016005 .
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: We declare that we have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hua-Guo Xu, MD, PhD, Professor, Research Scientist, Department of Laboratory Medicine, The First Affiliated Hospital, Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. huaguoxu@njmu.edu.cn
Received: July 12, 2020
Peer-review started: July 12, 2020
First decision: August 8, 2020
Revised: August 21, 2020
Accepted: September 10, 2020
Article in press: September 10, 2020
Published online: October 26, 2020
Processing time: 105 Days and 20.2 Hours
Peer-review started: July 12, 2020
First decision: August 8, 2020
Revised: August 21, 2020
Accepted: September 10, 2020
Article in press: September 10, 2020
Published online: October 26, 2020
Processing time: 105 Days and 20.2 Hours
Core Tip
Core Tip: Hemophagocytic lymphohistiocytosis (HLH) is a rare immune-mediated life-threatening disease. Active HLH develops rapidly, and the mortality rate is high if reasonable and effective interventions are not promptly undertaken. Herein, we report a case of a 31-year-old Chinese woman diagnosed with systemic autoimmune abnormalities complicated by cytomegalovirus (CMV)-induced HLH. The patient has been cured and has not relapsed for 6 years. This report may act as a reference for HLH therapy in cases positive for anti-nuclear antibody and CMV.