Forniceal deep brain stimulation in severe Alzheimer’s disease: A case report

Table 1 Cerebrospinal fluid assessment results (upper three lines) and neuropsychological assessment results (lower five lines) before and after f-deep brain stimulation treatment

Assessments	Preoperative	Postoperative at 3 mo	Ref.
Aβ1-42	172.6 pg/mL	N/A	890-2980 pg/mL
tau	322 pg/mL	N/A	103-218 pg/mL
ptau	52.44 pg/mL	N/A	28.5-42.3 pg/mL
ADL	65	47	20-26
MMSE	1	1	27-30
MoCA-B	0	0	26-30
CDR	2	2	0
GDS	6	6	1

Aβ_1-42: Cerebrospinal fluid amyloid-beta 1-42 level; tau: Cerebrospinal fluid tau protein level; ptau: Cerebrospinal fluid phosphorylated tau protein level; ADL: Activities of daily living; MMSE: Mini-mental state examination; MoCA-B: Montreal cognitive assessment basic; CDR: Clinical dementia rating; GDS: Global deterioration scale; N/A: Not available.

Table 2 Preoperative activities of daily living

Take a bus	4	Go up/downstairs	2
Go to a place near home, within walking distance	3	Get on/off bed, sit down/stand up	1
Prepare meal	4	Fetch water to cook/bathe	4
Do the housework	4	Take a bath	4
Take medicine	1	Cut toenail	4
Eat meal	3	Go shopping	4
Put on/take off clothes	4	Go to the toilet regularly	3
Brush hair/teeth	3	Make a phone call	4
Wash clothes	4	Take care of the money	4
Walk on flat floor indoors	1	Be home alone	4

Write down numeric points: 1 = can do it myself, 2 = have some difficulty doing but can still do it by myself, 3 = need help to do it, 4 = cannot do it at all.

Table 3 Postoperative activities of daily living at 3 mo

Take a bus	3	Go up/downstairs	2
Go to a place near home, within walking distance	2	Get on/off bed, sit down/stand up	1
Prepare meal	4	Fetch water to cook/bathe	3
Do the housework	3	Take a bath	2
Take medicine	1	Cut toenail	2
Eat meal	1	Go shopping	2
Put on/take off clothes	2	Go to the toilet regularly	2
Brush hair/teeth	2	Make a phone call	3
Wash clothes	4	Take care of the money	4
Walk on flat floor indoors	1	Be home alone	3

Write down numeric points: 1 = can do it myself; 2 = have some difficulty doing but can still do it by myself; 3 = need help to do it; 4 = cannot do it at all.