Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2020; 8(20): 4938-4945
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4938
Forniceal deep brain stimulation in severe Alzheimer’s disease: A case report
Wei Lin, Wei-Qi Bao, Jing-Jie Ge, Li-Kun Yang, Zhi-Pei Ling, Xin Xu, Jie-Hui Jiang, Chuan-Tao Zuo, Yu-Hai Wang
Wei Lin, Li-Kun Yang, Yu-Hai Wang, Department of Neurosurgery, Joint Logistics Support Unit No. 904 Hospital, Wuxi 214044, Jiangsu Province, China
Wei-Qi Bao, Jing-Jie Ge, Chuan-Tao Zuo, PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Zhi-Pei Ling, Xin Xu, Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing 100039, China
Jie-Hui Jiang, School of Communication and Information Technology, Institute of Biomedical Engineering, Shanghai University, Shanghai 200444, China
Author contributions: Lin W drafted the manuscript, conducted the deep brain stimulation (DBS) surgery, analyzed the neuropsychological data, and designed the study; Bao WQ, Ge JJ, and Jiang JH drafted the manuscript, acquired and analyzed the PET data, and designed the study; Yang LK, Ling ZP, and Xu X revised the manuscript, conducted DBS surgery, analyzed neuropsychological data, and designed the study; Zuo CT critically revised the manuscript for important intellectual content, analyzed and edited PET data, and conceived the study; Wang YH critically revised the manuscript for important intellectual content, conducted the DBS surgery, analyzed and edited neuropsychological data, and conceived the study.
Informed consent statement: Informed consent to publish was obtained from the patient.
Conflict-of-interest statement: All the authors of this article declare that there is no conflict of interest regarding the publication of this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yu-Hai Wang, MD, MNAMS, Doctor, Department of Neurosurgery, Joint Logistics Support Unit No. 904 Hospital, No. 101 Xingyuan Road North, Wuxi 214044, Jiangsu Province, China. wangyuhai67@126.com
Received: May 11, 2020
Peer-review started: May 11, 2020
First decision: June 7, 2020
Revised: June 11, 2020
Accepted: September 16, 2020
Article in press: September 16, 2020
Published online: October 26, 2020
Processing time: 163 Days and 0.7 Hours
Core Tip

Core Tip: A longitudinal case study for one severe Alzheimer’s disease patient showed that forniceal deep brain stimulation may improve the activities of daily living rather than cognitive functions after 3 mo of continuous stimulation through elevating regional glucose metabolism in the brain.