Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis

doi:10.12998/wjcc.v8.i19.4320

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Oct 6, 2020 (publication date) through Nov 4, 2024

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Clin Cases. Oct 6, 2020; 8(19): 4320-4330
Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4320

Table 1 Demographic characteristics and associated risk factors in tuberculosis patients vs. healthy controls

	TB patients (n = 503)		Healthy controls (n = 494)		χ²	P value
	n	%	n	%	χ²	P value
Sex
Male	369	73.36	348	70.45	1.048	0.306
Female	134	26.64	146	29.55
Age, yr
18-30	68	13.52	78	15.79	1.908	0.592
31-50	190	37.77	178	36.03
51-70	167	32.20	153	30.97
> 70	78	15.51	85	17.21
Marital status
Married	345	68.59	330	66.80	0.364	0.546
Other	158	31.41	164	33.20
Educational background
Primary school or below	198	39.36	220	44.53	2.824	0.244
Junior high school	161	32.01	148	29.96
Senior high school or above	144	28.63	126	25.51
BMI, kg/m²
< 18.5	180	35.79	169	34.21	9.310	0.010^a
18.5-24.9	297	59.05	274	55.47
≥ 25.0	26	5.17	51	10.32
History of BCG vaccination
Yes	105	20.87	141	28.54	7.884	0.005^a
No	398	79.13	353	71.46
Smoking
Yes	298	59.24	240	48.58	11.403	< 0.001^a
No	205	40.76	254	51.42
Alcohol drinking
Yes	91	18.09	77	15.59	1.116	0.291
No	412	81.91	417	84.41
Tea drinking
Yes	247	49.11	293	59.31	10.457	0.001^a
No	256	50.89	201	40.69

^aP < 0.05. TB: Tuberculosis; BMI: Body mass index; BCG: Bacillus Calmette–Guérin.

Table 2 Genotypes of the mTOR gene in the two groups

		TB patients		Healthy controls		χ²	P value
		n	%	n	%	χ²	P value
rs2295080	TT	286	56.86	323	65.38	9.621	0.008^a
	GT	191	37.97	158	31.98
	GG	26	5.17	13	2.63
HWE-P				0.220
rs2024627	CC	406	80.72	429	86.84	6.989	0.030^a
	CT	93	18.49	63	12.75
	TT	4	0.80	2	0.40
HWE-P				0.847
rs1057079	TT	271	53.88	330	66.80	19.708	< 0.001^a
	CT	204	40.56	152	30.77
	CC	28	5.57	12	2.43
HWE-P				0.259
rs12137958	GG	414	82.31	419	84.82	1.626	0.526
	AG	87	17.30	72	14.57
	AA	2	0.40	3	0.61
HWE-P				0.961
rs7525957	TT	368	73.16	402	81.38	9.568	0.008^a
	CT	126	25.05	86	17.41
	CC	9	1.79	6	1.21
HWE-P				0.566

^aP < 0.05. TB: Tuberculosis; HWE-P: Hardy-Weinberg equilibrium-P value.

Table 3 mTOR gene polymorphism vs. tuberculosis incidence

		TB patients		Healthy controls		OR_c (95%CI)	OR_a¹ (95%CI)
		n	%	n	%	OR_c (95%CI)	OR_a¹ (95%CI)
rs2295080	TT	286	56.86	323	65.38	1	1
	GT	191	37.97	158	31.98	1.365 (1.048-1.778)	1.334 (1.018-1.749)^a
	GG	26	5.17	13	2.63	2.259 (1.139-4.479)	2.224 (1.110-4.458)^a
	GT + GG	217	43.14	171	34.61	1.433 (1.110-1.851)	1.403 (1.080-1.823)^a
rs2024627	CC	406	80.72	429	86.84	1	1
	CT	93	18.49	63	12.75	1.560 (1.102-2.208)	1.562 (1.096-2.226)^a
	TT	4	0.80	2	0.40	2.113 (0.385-11.600)	2.069 (0.369-11.607)
	CT + TT	97	19.29	65	13.15	1.577 (1.120-2.220)	1.578 (1.113-2.237)^a
rs1057079	TT	271	53.88	330	66.80	1	1
	CT	204	40.56	152	30.77	1.634 (1.255-2.129)	1.597 (1.216-2.097)^a
	CC	28	5.57	12	2.43	2.841 (1.418-5.694)	2.858 (1.404-5.818)^a
	CT + CC	232	46.13	164	33.20	1.723 (1.333-2.226)	1.682 (1.290-2.194)^a
rs12137958	GG	414	82.31	419	84.82	1	1
	AG	87	17.30	72	14.57	1.223 (0.870-1.719)	1.187 (0.840-1.678)
	AA	2	0.40	3	0.61	0.675 (0.112-4.059)	0.879 (0.144-5.379)
	AG + AA	89	17.70	75	15.18	1.201 (0.858-1.680)	1.176 (0.836-1.656)
rs7525957	TT	368	73.16	402	81.38	1	1
	CT	126	25.05	86	17.41	1.600 (1.176-2.179)	1.559 (1.138-2.136)^a
	CC	9	1.79	6	1.21	1.639 (0.578-4.648)	1.686 (0.588-4.831)
	CT + CC	135	26.84	92	18.62	1.603 (1.187-2.165)	1.568 (1.154-2.130)^a

^aP < 0.05.

¹Adjusted for the covariates of sex, age, marital status, educational background, body mass index, smoking status, alcohol drinking, tea drinking and Bacillus Calmette–Guérin vaccination. TB: Tuberculosis.

Table 4 Impact of interactions between genotypes of mTOR gene and tea drinking on incidence of tuberculosis

		Tea drinking		RERI_c	RERI_a¹ (95%CI)
		No	Yes
rs2295080	TT	245	364	-2.0341	-1.5187 (-1.9826, -1.0547)^a
rs2295080	GT + GG	212	176	-2.0341	-1.5187 (-1.9826, -1.0547)^a
rs2024627	CC	367	468	-1.6561	-1.8270 (-2.3587, -1.2952)^a
rs2024627	CT + TT	90	72	-1.6561	-1.8270 (-2.3587, -1.2952)^a
rs1057079	TT	228	373	-2.7054	-2.3246 (-2.9417, -1.7076)^a
rs1057079	CT + CC	229	167	-2.7054	-2.3246 (-2.9417, -1.7076)^a
rs7525957	TT	326	444	-1.3684	-0.4235 (-0.7756, -0.0714)^a
rs7525957	CT + CC	131	96	-1.3684	-0.4235 (-0.7756, -0.0714)^a

¹Adjusted for the covariates of sex, age, marital status, educational background, body mass index, smoking status, alcohol drinking and Bacillus Calmette–Guérin vaccination.

^aP < 0.05, RERI < 0 suggests negative interactions. RERI: Relative excess risk of interaction.

Citation: Wang M, Ma SJ, Wu XY, Zhang X, Abesig J, Xiao ZH, Huang X, Yan HP, Wang J, Chen MS, Tan HZ. Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis. World J Clin Cases 2020; 8(19): 4320-4330
URL: https://www.wjgnet.com/2307-8960/full/v8/i19/4320.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i19.4320