Significance of serum fibroblast growth factor-23 and miR-208b in pathogenesis of atrial fibrillation and their relationship with prognosis

Table 1 Comparison of general data between the two groups, n (%)

Group	n	Male	Age (yr)	BMI (kg/m2)	Smoking	Drinking
Observation	240	168 (70.00)	60.50 ± 9.28	23.30 ± 5.44	103 (42.92)	63 (26.25)
Control	150	98 (65.33)	59.22 ± 10.11	22.83 ± 6.50	56 (37.33)	34 (22.67)
t/χ2		0.927	1.280	0.769	1.192	0.634
P value		0.336	0.201	0.442	0.275	0.426

BMI: Body mass index.

Table 2 Comparison of serum fibroblast growth factor-23 and miR-208b levels in the two groups

Group	n	FGF-23 (ng/mL)	Relative expression of miR-208b
Observation	240	210.20 ± 89.60	5.30 ± 1.22
Control	150	110.04 ± 32.29	2.90 ± 0.88
t		13.162	20.926
P value		0.000	0.000

FGF: Fibroblast growth factor.

Table 3 Comparison of serum fibroblast growth factor-23 and miR-208b in different subgroups of observation group

Group	n	Man, n (%)	Age (yr)	FGF-23 (ng/mL)	Relative expression of miR-208b	LAD (mm)	LVEDD (mm)	LVESD (mm)	LVEF (%)
Paroxysmal atrial fibrillation	134	98 (73.13)	61.02 ± 10.11	191.20 ± 65.59	4.88 ± 1.02	34.03 ± 4.02	50.03 ± 6.03	32.10 ± 5.58	53.30 ± 7.81
Persistent atrial fibrillation	106	70 (66.04)	59.89 ± 9.92	234.22 ± 70.05	5.83 ± 1.00	38.81 ± 5.11	49.81 ± 5.82	32.01 ± 6.02	52.83 ± 8.10
t		1.419	0.867	-4.896	-7.227	-8.112	0.285	0.120	0.455
P value		0.234	0.387	0.000	0.000	0.000	0.776	0.905	0.649

FGF: Fibroblast growth factor; LAD: Left atrial dimension; LVEDD: Left ventricular end diastolic diameter; LVEF: Left ventricular ejection fraction; LVESD: Left ventricular end-systolic diameter.

Table 4 Comparison of serum fibroblast growth factor-23 and miR-208b in patients with and without a major cardiovascular event

Group	n	Man, n (%)	Age (yr)	FGF-23 (ng/mL)	Relative expression of miR-208b
MACE	58	43 (74.14)	61.19 ± 10.54	243.30 ± 72.29	6.12 ± 1.12
Non-MACE	182	125 (68.68)	62.28 ± 9.89	199.65 ± 71.43	5.04 ± 1.07
t		0.624	-0.719	4.041	6.619
P value		0.43	0.473	0.000	0.000

FGF: Fibroblast growth factor; MACE: Major cardiovascular event.