Correlation between age of onset and gastrointestinal stenosis in hospitalized patients with Crohn's disease

Table 1 Demographic variables and disease characteristics of Crohn’s disease

Variable	No. or median/mean	% or range
Total number of patients	122
Male gender	85	69.67
Age of onset (yr)	34.72	15.15
Duration of disease (mo)	64	1-492
Gastrointestinal stenosis	72	59.02
L1	33	27.05
L2	27	22.13
L3	59	48.36
L4	2	1.64
L1 + L4	1	0.82
B1 (B1p)	42 (5)	34.43
B2 (B2p)	65 (2)	53.28
B3 (B3p)	8 (1)	6.56
B2 + B31	7	5.74
Disease activity: Mild	25	20.49
Disease activity: Moderate	84	68.85
Disease activity: Severe	13	10.66

¹As the disease progresses, stricturing and penetrating disease behaviors can coexist. L and B: The phenotype of the Montreal classification of inflammatory bowel disease. p: Combined with perianal disease[29].

Table 2 Univariate comparison between gastrointestinal stenosis group and non-gastrointestinal stenosis group

Variable	Gastrointestinal stenosis	Non-gastrointestinal stenosis	P value
Total number of patients	72 (59.02%)	50 (40.98%)
Male gender	49 (68.06%)	36 (72.00%)	0.761
Age of onset (yr)	37.61 ± 15.14	30.84 ± 14.67	0.021
Duration of disease (mo)	72 (11-492)	45 (3-240)	0.010
Exposure to corticosteroid	23	20	0.360
Exposure to azathioprine	22	13	0.247
Exposure to biologics	35	19	0.585
Disease activity: Severe	11	2	0.065
Disease involved: Ileum	50	44	0.039
Parenteral performance	5	6	0.243
Perforation	4	4	0.594
Gastrointestinal bleeding	5	1	0.243
Thrombosis	1	0	NA
Fistula	7	10	0.114
Severe malnutrition	9	5	0.671
Infection	7	6	0.689
Neoplastic lesions	1	1	0.795

NA: Not available.

Table 3 Multivariable logistic regression analysis between gastrointestinal stenosis group and non-gastrointestinal stenosis group

Variable	β	SE	Odds ratio (95%CI)	P value
Age of onset	0.028	0.014	1.028 (1.000-1.056)	0.046
Duration of disease	0.008	0.003	1.008 (1.002-1.015)	0.013
Fistula	-0.833	0.587	0.435 (0.138-1.373)	0.156
Disease activity: Severe	1.524	0.841	4.593 (0.883-23.896)	0.070
Disease involved: Ileum	-1.003	0.525	0.367 (0.131-1.025)	0.056

CI: Confidence interval.

Table 4 Correlation between age of onset or duration of disease and Crohn's disease-related gastrointestinal stenosis

Variable	Gastrointestinal stenosis (n = 72)	Non-gastrointestinal stenosis (n = 50)	P value	OR (95%CI)
Age of onset > 40 yr	29	9	0.009	3.072 (1.298-7.272)
Age of onset ≤ 40 yr	43	41
Duration of disease > 5 yr	39	18	0.048	2.101 (1.002-4.406)
Duration of disease ≤ 5 yr	33	32

OR: Odds ratio; CI: Confidence interval.

Table 5 Treatments for Crohn's disease-related gastrointestinal stenosis

Variable	n	%
Total number of patients	72
Internal medicine and nutrition treatment	15	20.83
Surgical treatment	52	72.22
Endoscopic therapy	21	29.17
Surgical treatment
Reoperation	6	11.54
Postoperative complications	8	15.38
Endoscopic therapy
No surgery events	16	76.19
Undergo surgery	5	23.81
Postoperative complications	0	0